Alzheimer's disease (AD) stands as the predominant form of dementia, presenting significant
and escalating global challenges. Its etiology is intricate and diverse, stemming from a …

Senile plaques induced by β-amyloid (Aβ) abnormal aggregation and neurofibrillary tangles
(NFT) caused by tau hyperphosphorylation are important pathological manifestations of …

Nrf2 is a major transcription factor that significantly regulates—directly or indirectly—more
than 2000 genes. While many of these genes are involved in maintaining redox balance …

Neurodegenerative diseases (NDs) are one of the prominent health challenges facing
contemporary society, and many efforts have been made to overcome and (or) control it. In …

Parkinson's disease (PD) is a progressive neurodegenerative disease of the brain due to
degeneration of dopaminergic neurons in the substantia nigra (SN). Glycogen synthase …

Innovations in cancer immunotherapy have resulted in the development of several novel
immunotherapeutic strategies that can disrupt immunosuppression. One key advancement …

Neuronal cells overexpressing phosphorylated Tau proteins can increase the susceptibility
to oxidative stress. Regulation of glycogen synthase-3β (GSK-3β) and reduction of Tau …

Small-molecule-inhibitor-based bone differentiation has been recently exploited as a novel
approach to regulating osteogenesis-related signaling pathways. In this study, we identified …

GSK-3β, IKK-β, and ROCK-1 kinases are implicated in the pathomechanism of Alzheimer's
disease due to their involvement in the misfolding and accumulation of amyloid β (Aβ) and …

Background Alzheimer's disease (AD) pathogenesis is complex. The pathophysiology is not
fully understood, and safe and effective treatments are needed. Glycogen synthase kinase …