Radial glia are specialized cells in the develo** nervous system of all vertebrates, and are
characterized by long radial processes. These processes facilitate the best known function …

The development of the vertebrate brain involves the creation of many cell types in precise
locations and at precise times, followed by the formation of functional connections. To …

Abstract The protein Sonic hedgehog (Shh) controls patterning and growth during vertebrate
development. Here we demonstrate that it binds Patched (vPtc), which has been identified …

Advances in neuroimaging, developmental biology and molecular genetics have increased
the understanding of developmental disorders affecting the midbrain and hindbrain, both as …

In the spinal cord, sonic hedgehog (Shh) is secreted by the floor plate to control the
generation of distinct classes of ventral neurons along the dorsoventral axis. Genetic and in …

This study addresses the role of Sonic hedgehog (Shh) in promoting the generation of
oligodendrocytes in the mouse telencephalon. We show that in the forebrain, expression of …

In the spinal neural tube, populations of neuronal precursors that express a unique
combination of transcription factors give rise to specific classes of neurons at precise …

Considerable data suggest that sonic hedgehog (Shh) is both necessary and sufficient for
the specification of ventral pattern throughout the nervous system, including the …

Anteroposterior polarity in the vertebrate limb is thought to be regulated in response to
signals derived from a specialized region of distal posterior mesenchyme, the zone of …

From an architectural point of view, the forebrain acts as a framework upon which the middle
and upper face develops and grows. In addition to serving a structural role, we present …