How biology handles nitrite

LB Maia, JJG Moura - Chemical Reviews, 2014 - ACS Publications
Nitrite is one of the players in the broad nitrogen biogeochemical cycle. This nitrogen oxo-
anion is involved in key pathways crucial to life on Earth and to the planetary “recycling” of …

Function and evolution of vertebrate globins

T Burmester, T Hankeln - Acta Physiologica, 2014 - Wiley Online Library
Globins are haem‐proteins that bind O2 and thus play an important role in the animal's
respiration and oxidative energy production. However, globins may also have other …

Human neuroglobin functions as a redox-regulated nitrite reductase

M Tiso, J Tejero, S Basu, I Azarov, X Wang… - Journal of Biological …, 2011 - ASBMB
Neuroglobin is a highly conserved hemoprotein of uncertain physiological function that
evolved from a common ancestor to hemoglobin and myoglobin. It possesses a six …

Structure and reactivity of hexacoordinate hemoglobins

S Kakar, FG Hoffman, JF Storz, M Fabian… - Biophysical …, 2010 - Elsevier
The heme prosthetic group in hemoglobins is most often attached to the globin through
coordination of either one or two histidine side chains. Those proteins with one histidine …

Neuroglobin: From structure to function in health and disease

P Ascenzi, A di Masi, L Leboffe, M Fiocchetti… - Molecular aspects of …, 2016 - Elsevier
In 2000, the third member of the globin family was discovered in human and mouse brain
and named neuroglobin (Ngb). Ngb is a monomeric 3/3 globin structurally similar to …

Neuroglobin, cytoglobin, and myoglobin contribute to hypoxia adaptation of the subterranean mole rat Spalax

A Avivi, F Gerlach, A Joel, S Reuss… - Proceedings of the …, 2010 - National Acad Sciences
The subterranean mole rat Spalax is an excellent model for studying adaptation of a
mammal toward chronic environmental hypoxia. Neuroglobin (Ngb) and cytoglobin (Cygb) …

Mutations in FLVCR1 cause posterior column ataxia and retinitis pigmentosa

AM Rajadhyaksha, O Elemento… - The American Journal of …, 2010 - cell.com
The study of inherited retinal diseases has advanced our knowledge of the cellular and
molecular mechanisms involved in sensory neural signaling. Dysfunction of two specific …

Neuroglobin protects astroglial cells from hydrogen peroxide‐induced oxidative stress and apoptotic cell death

F Amri, I Ghouili, M Amri, A Carrier… - Journal of …, 2017 - Wiley Online Library
Oxidative stress, resulting from accumulation of reactive oxygen species, plays a critical role
in astroglial cell death occurring in diverse neuropathological conditions. Numerous studies …

Neuroglobin protects neurons against oxidative stress in global ischemia

RC Li, SZ Guo, SK Lee, D Gozal - Journal of Cerebral Blood …, 2010 - journals.sagepub.com
Neuroglobin (Ngb) is a recently discovered globin that affords protection against
hypoxic/ischemic-induced cell injury in brain. Hypoxic/ischemic injury is associated with …

Neuroglobin, clues to function and mechanism

C Exertier, LC Montemiglio, I Freda, E Gugole… - Molecular Aspects of …, 2022 - Elsevier
Neuroglobin is expressed in vertebrate brain and belongs to a branch of the globin family
that diverged early in evolution. Sequence conservation and presence in nervous cells of …