Exciting new discoveries have transformed the view of the lysosome from a static organelle
dedicated to the disposal and recycling of cellular waste to a highly dynamic structure that …

The late endosomes/endo‐lysosomes of vertebrates contain an atypical phospholipid,
lysobisphosphatidic acid (LBPA)(also termed bis [monoacylglycero] phosphate [BMP]) …

Lysosomes require an acidic lumen between pH 4.5 and 5.0 for effective digestion of
macromolecules. This pH optimum is maintained by proton influx produced by the V-ATPase …

Potassium (K+) efflux across the plasma membrane is thought to be an essential mechanism
for ATP-induced NLRP3 inflammasome activation, yet the identity of the efflux channel has …

Compelling evidence has demonstrated that macroautophagy/autophagy plays an important
role in regulating multiple steps of metastatic cascades; however, the precise role of …

The endomembrane system consists of organellar membranes in the biosynthetic pathway
[endoplasmic reticulum (ER), Golgi apparatus, and secretory vesicles] as well as those in the …

Mutations in the human ATP13A2 (PARK9), a lysosomal ATPase, cause Kufor-Rakeb
Syndrome, an early-onset form of Parkinson's disease (PD). Here, we demonstrate that …

Recent developments in lysosome biology have transformed our view of lysosomes from
static garbage disposals that can also act as suicide bags to decidedly dynamic multirole …

Lysosomes, the degradation center of the cell, are filled with acidic hydrolases. Lysosomes
generate nutrient-sensitive signals to regulate the import of H+, hydrolases, and endocytic …

Macroautophagy/autophagy is elevated to ensure the high demand for nutrients for the
growth of cancer cells. Here we demonstrated that MCOLN1/TRPML1 is a pharmaceutical …