During thymic development, thymocytes adjust their TCR response based on the strength of
their reactivity to self-peptide MHC complexes. This tuning process allows thymocytes with a …

There is a long-standing assumption that naive CD4+ and CD8+ T cells are largely
homogeneous populations despite the extraordinary diversity of their T cell receptors (TCR) …

Production of effector CD8+ T cells during persistent infection requires a stable pool of stem-
like cells that can give rise to effector cells via a proliferative intermediate population. In …

Functional tuning of T cells based on their degree of self-reactivity is established during
positive selection in the thymus, although how positive selection differs for thymocytes with …

The breadth of pathogens to which T cells can respond is determined by the T cell receptors
(TCRs) present in an individual's repertoire. Although more than 90% of the sequence …

Moritella viscosa (M. viscosa) and sea lice (Lepeophtheirus salmonis) are severe pathogens
that primarily infect the skin of Atlantic salmon (Salmo salar), which cause significant …

Certain CD8 T cell responses are particularly effective at controlling infection, as exemplified
by elite control of HIV in individuals harboring HLA-B57. To understand the structural …

T cells form an indispensable component of vertebrate immune function. The primary goal of
effector T cells is to recognize and respond to invading threats in a highly pathogen-specific …

Certain CD8 T cell responses are particularly effective at controlling infection, as exemplified
by elite control of HIV in individuals harboring HLA-B57. To understand the structural …

Certain CD8 T cell responses are particularly effective at controlling infection, as exemplified
by elite control of HIV in individuals harboring HLA-B57. To understand the structural …