The use of artificial intelligence (AI) and machine learning (ML) in pharmaceutical research
and development has to date focused on research: target identification; docking-, fragment …

Detecting drug–drug interactions (DDIs) is an essential step in drug development and drug
administration. Given the shortcomings of current experimental methods, the machine …

Melanoma is one of the most dangerous types of skin cancer that its early detection can
save patients' lives. Computer‐aided methods can be used for this early detection with …

DNA-binding proteins (DBPs) not only play an important role in all aspects of genetic
activities such as DNA replication, recombination, repair, and modification but also are used …

Motivation Approaches for the diagnosis and treatment of diseases often adopt the multidrug
therapy method because it can increase the efficacy or reduce the toxic side effects of drugs …

Treatments consisting of mixtures of pharmacological agents have been shown to have
superior effects to treatments involving single compounds. Given the vast amount of possible …

In recent years, due to the complementary action of drug combinations over mono-therapy,
the multiple-drugs for multiple-targets paradigm has received increased attention to treat …

The threat to global health posed by unpredictable infections and increasing antimicrobial
resistance necessitates the urgent development of drug combination therapies (DCBs) for …

Metabolic reactions in the body transform the administered drug into metabolites. These
metabolites exhibit diverse biological activities. Drug metabolism is the major underlying …

Background: Determination or prediction of the Absorption, Distribution, Metabolism, and
Excretion (ADME) properties of drug candidates and drug-induced toxicity plays crucial roles …