Vascular mechanotransduction
This review aims to survey the current state of mechanotransduction in vascular smooth
muscle cells (VSMCs) and endothelial cells (ECs), including their sensing of mechanical …
muscle cells (VSMCs) and endothelial cells (ECs), including their sensing of mechanical …
PIP2 Is a Necessary Cofactor for Ion Channel Function: How and Why?
BC Suh, B Hille - Annu. Rev. Biophys., 2008 - annualreviews.org
Phosphatidylinositol 4, 5-bisphosphate (PIP2) is a minority phospholipid of the inner leaflet
of plasma membranes. Many plasma membrane ion channels and ion transporters require …
of plasma membranes. Many plasma membrane ion channels and ion transporters require …
Structure of acid-sensing ion channel 1 at 1.9 Å resolution and low pH
Acid-sensing ion channels (ASICs) are voltage-independent, proton-activated receptors that
belong to the epithelial sodium channel/degenerin family of ion channels and are implicated …
belong to the epithelial sodium channel/degenerin family of ion channels and are implicated …
Crystal structure of the ATP-gated P2X4 ion channel in the closed state
P2X receptors are cation-selective ion channels gated by extracellular ATP, and are
implicated in diverse physiological processes, from synaptic transmission to inflammation to …
implicated in diverse physiological processes, from synaptic transmission to inflammation to …
Fluorescence-detection size-exclusion chromatography for precrystallization screening of integral membrane proteins
T Kawate, E Gouaux - Structure, 2006 - cell.com
Formation of well-ordered crystals of membrane proteins is a bottleneck for structure
determination by X-ray crystallography. Nevertheless, one can increase the probability of …
determination by X-ray crystallography. Nevertheless, one can increase the probability of …
Epithelial sodium channel (ENaC) family: Phylogeny, structure–function, tissue distribution, and associated inherited diseases
The epithelial sodium channel (ENaC) is composed of three homologous subunits and
allows the flow of Na+ ions across high resistance epithelia, maintaining body salt and water …
allows the flow of Na+ ions across high resistance epithelia, maintaining body salt and water …
Molecular basis of human sperm capacitation
In the early 1950s, Austin and Chang independently described the changes that are
required for the sperm to fertilize oocytes in vivo. These changes were originally grouped …
required for the sperm to fertilize oocytes in vivo. These changes were originally grouped …
Cryo-EM structure of TMEM63C suggests it functions as a monomer
Y Qin, D Yu, D Wu, J Dong, WT Li, C Ye… - Nature …, 2023 - nature.com
The TMEM63 family proteins (A, B, and C), calcium-permeable channels in animals that are
preferentially activated by hypo-osmolality, have been implicated in various physiological …
preferentially activated by hypo-osmolality, have been implicated in various physiological …
Advanced taste sensors based on artificial lipids with global selectivity to basic taste qualities and high correlation to sensory scores
Y Kobayashi, M Habara, H Ikezazki, R Chen, Y Naito… - Sensors, 2010 - mdpi.com
Effective R&D and strict quality control of a broad range of foods, beverages, and
pharmaceutical products require objective taste evaluation. Advanced taste sensors using …
pharmaceutical products require objective taste evaluation. Advanced taste sensors using …
Role of ion channels and transporters in cell migration
A Schwab, A Fabian, PJ Hanley… - Physiological …, 2012 - journals.physiology.org
Cell motility is central to tissue homeostasis in health and disease, and there is hardly any
cell in the body that is not motile at a given point in its life cycle. Important physiological …
cell in the body that is not motile at a given point in its life cycle. Important physiological …