[HTML][HTML] Quality control of the mitochondrion
Mitochondria are essential organelles that execute and coordinate various metabolic
processes in the cell. Mitochondrial dysfunction severely affects cell fitness and contributes …
processes in the cell. Mitochondrial dysfunction severely affects cell fitness and contributes …
Circadian clocks and insulin resistance
Insulin resistance is a main determinant in the development of type 2 diabetes mellitus and a
major cause of morbidity and mortality. The circadian timing system consists of a central …
major cause of morbidity and mortality. The circadian timing system consists of a central …
Time-restricted feeding prevents obesity and metabolic syndrome in mice lacking a circadian clock
Increased susceptibility of circadian clock mutant mice to metabolic diseases has led to the
idea that a molecular clock is necessary for metabolic homeostasis. However, these mice …
idea that a molecular clock is necessary for metabolic homeostasis. However, these mice …
Crosstalk between metabolism and circadian clocks
H Reinke, G Asher - Nature Reviews Molecular Cell Biology, 2019 - nature.com
Humans, like all mammals, partition their daily behaviour into activity (wakefulness) and rest
(sleep) phases that differ largely in their metabolic requirements. The circadian clock …
(sleep) phases that differ largely in their metabolic requirements. The circadian clock …
Interconnections between circadian clocks and metabolism
Circadian rhythms evolved through adaptation to daily light/dark changes in the
environment; they are believed to be regulated by the core circadian clock interlocking …
environment; they are believed to be regulated by the core circadian clock interlocking …
Disruption of the circadian clock component BMAL1 elicits an endocrine adaption impacting on insulin sensitivity and liver disease
Obesity and liver diseases are associated with the disruption of the circadian clock that
orchestrates mammalian physiology to optimize nutrient metabolism and storage. Here, we …
orchestrates mammalian physiology to optimize nutrient metabolism and storage. Here, we …
Targeting glioblastoma stem cells through disruption of the circadian clock
Glioblastomas are highly lethal cancers, containing self-renewing glioblastoma stem cells
(GSC). Here, we show that GSCs, differentiated glioblastoma cells (DGC), and nonmalignant …
(GSC). Here, we show that GSCs, differentiated glioblastoma cells (DGC), and nonmalignant …
Circadian clock regulation of hepatic lipid metabolism by modulation of m6A mRNA methylation
X Zhong, J Yu, K Frazier, X Weng, Y Li, CM Cham… - Cell reports, 2018 - cell.com
Transcriptional regulation of circadian rhythms is essential for lipid metabolic homeostasis,
disruptions of which can lead to metabolic diseases. Whether N 6-methyladenosine (m 6 A) …
disruptions of which can lead to metabolic diseases. Whether N 6-methyladenosine (m 6 A) …
Role and mechanisms of mitophagy in liver diseases
The mitochondrion is an organelle that plays a vital role in the regulation of hepatic cellular
redox, lipid metabolism, and cell death. Mitochondrial dysfunction is associated with both …
redox, lipid metabolism, and cell death. Mitochondrial dysfunction is associated with both …
Circadian system and glucose metabolism: implications for physiology and disease
The circadian system serves one of the most fundamental properties present in nearly all
organisms: it generates 24-h rhythms in behavioral and physiological processes and …
organisms: it generates 24-h rhythms in behavioral and physiological processes and …