Defeating AIDS—advancing global health

P Piot, SSA Karim, R Hecht, H Legido-Quigley, K Buse… - The Lancet, 2015 - thelancet.com
Executive summary After more than a decade of major achievements, the AIDS response is
at a crucial juncture, both in terms of its immediate trajectory and its sustainability, as well as …

Antiretrovirals for reducing the risk of mother‐to‐child transmission of HIV infection

N Siegfried, L van der Merwe… - … of systematic reviews, 2011 - cochranelibrary.com
Background Antiretroviral drugs reduce viral replication and can reduce mother‐to‐child
transmission of HIV either by lowering plasma viral load in pregnant women or through post …

Effectiveness and safety of tenofovir gel, an antiretroviral microbicide, for the prevention of HIV infection in women

Q Abdool Karim, SS Abdool Karim, JA Frohlich… - science, 2010 - science.org
The Centre for the AIDS Program of Research in South Africa (CAPRISA) 004 trial assessed
the effectiveness and safety of a 1% vaginal gel formulation of tenofovir, a nucleotide …

Mortality of infected and uninfected infants born to HIV-infected mothers in Africa: a pooled analysis

ML Newell, H Coovadia, M Cortina-Borja, N Rollins… - The Lancet, 2004 - thelancet.com
Background HIV contributes substantially to child mortality, but factors underlying these
deaths are inadequately described. With individual data from seven randomised mother-to …

Estimating the lost benefits of antiretroviral drug use in South Africa

P Chigwedere, GR Seage III, S Gruskin… - JAIDS Journal of …, 2008 - journals.lww.com
South Africa is one of the countries most severely affected by HIV/AIDS. At the peak of the
epidemic, the government, going against consensus scientific opinion, argued that HIV was …

Unraveling the divergent results of pre-exposure prophylaxis trials for HIV prevention

A Van der Straten, L Van Damme, JE Haberer… - Aids, 2012 - journals.lww.com
Although the balance of recent evidence supports the efficacy of antiretroviral (ARV)-based
pre-exposure prophylaxis (PrEP) against HIV-1 infection, recent negative trial results are …

Late postnatal transmission of HIV-1 in breast-fed children: an individual patient data meta-analysis

DJS Read… - The Journal of …, 2004 - academic.oup.com
Background. We analyzed individual patient data to determine the contribution of late
postnatal transmission to the overall risk of mother-to-child transmission of human …

Breastfeeding plus infant zidovudine prophylaxis for 6 months vs formula feeding plus infant zidovudine for 1 month to reduce mother-to-child HIV transmission in …

I Thior, S Lockman, LM Smeaton, RL Shapiro, C Wester… - Jama, 2006 - jamanetwork.com
ContextPostnatal transmission of human immunodeficiency virus-1 (HIV) via breastfeeding
reverses gains achieved by perinatal antiretroviral interventions. ObjectiveTo compare the …

Surrogate endpoints and FDA's accelerated approval process

TR Fleming - Health affairs, 2005 - healthaffairs.org
There is interest in approaches allowing more rapid availability of new interventions,
particularly for diseases providing risks of death or serious illness. The accelerated-approval …

[PDF][PDF] Private health insurance: implications for develo** countries

N Sekhri, W Savedoff - Bulletin of the World Health …, 2005 - SciELO Public Health
Los seguros médicos privados están desempeñando un papel cada vez más importante
tanto en los países de ingresos altos como en los países de ingresos bajos, pero los …