This review gives an account of the cigarette as a highly efficient nicotine delivery system. It
explains how nicotine induces pleasure, reduces stress and anxiety, and causes addiction …

Nicotine sustains tobacco addiction, a major cause of disability and premature death.
Nicotine binds to nicotinic cholinergic receptors, facilitating neurotransmitter release and …

Background: Given the rapid increase in the popularity of e-cigarettes and the paucity of
associated longitudinal health-related data, the need to assess the potential risks of long …

The polymorphic nature of the cytochrome P450 (CYP) genes affects individual drug
response and adverse reactions to a great extent. This variation includes copy number …

Rationale This review provides insight for the judicious selection of nicotine dose ranges
and routes of administration for in vivo studies. The literature is replete with reports in which …

Background The objective of this study was to summarize the published literature
concerning the epidemiology of lung cancer. Methods A narrative review of published …

The cytochromes P450 (CYPs) are key enzymes in cancer formation and cancer treatment.
They mediate the metabolic activation of numerous precarcinogens and participate in the …

Understanding the basic and clinical pharmacology of nicotine provides a basis for
improved prevention and treatment of tobacco addiction. Nicotine acts on nicotinic …

Abstract Coumarins (1, 2-benzopyrones) are ubiquitously found in higher plants where they
originate from the phenylpropanoid pathway. They contribute essentially to the persistence …

Warfarin anticoagulation effect is characterized by marked variability, some of which has
been attributed to CYP2C9 polymorphisms. This study prospectively examines whether a …