Targeting T-cell metabolism to boost immune checkpoint inhibitor therapy
H Li, A Zhao, M Li, L Shi, Q Han, Z Hou - Frontiers in immunology, 2022 - frontiersin.org
Immune checkpoint inhibitors (ICIs) have shown promising therapeutic effects in the
treatment of advanced solid cancers, but their overall response rate is still very low for …
treatment of advanced solid cancers, but their overall response rate is still very low for …
Lactate metabolism and immune modulation in breast cancer: a focused review on triple negative breast tumors
Triple negative breast cancer (TNBC) is an aggressive subtype of breast cancer associated
with poor prognosis, early recurrence, and the lack of durable chemotherapy responses and …
with poor prognosis, early recurrence, and the lack of durable chemotherapy responses and …
Lactate Dehydrogenase A or B Knockdown Reduces Lactate Production and Inhibits Breast Cancer Cell Motility in vitro
MA Khajah, S Khushaish, YA Luqmani - Frontiers in Pharmacology, 2021 - frontiersin.org
Background: Lactate dehydrogenase (LDH) plays an important role in cancer pathogenesis
and enhanced expression/activity of this enzyme has been correlated with poor prognosis …
and enhanced expression/activity of this enzyme has been correlated with poor prognosis …
The role of metabolic reprogramming in immune escape of triple-negative breast cancer
R Bao, H Qu, B Li, K Cheng, Y Miao… - Frontiers in …, 2024 - frontiersin.org
Triple-negative breast cancer (TNBC) has become a thorny problem in the treatment of
breast cancer because of its high invasiveness, metastasis and recurrence. Although …
breast cancer because of its high invasiveness, metastasis and recurrence. Although …
[HTML][HTML] Sperm proteins and cancer‐testis antigens are released by the seminiferous tubules in mice and men
Sperm develop from puberty in the seminiferous tubules, inside the blood‐testis barrier to
prevent their recognition as “non‐self” by the immune system, and it is widely assumed that …
prevent their recognition as “non‐self” by the immune system, and it is widely assumed that …
FANCA promotes lung adenocarcinoma progression and is a potential target for epitope vaccine immunotherapy
Y Kang, R Zhong, Y Gan, J You, J Chen, F Chen… - Journal of Translational …, 2024 - Springer
Background FANCA mutations have been detected in a variety of cancers and found to be
pro-carcinogenic. However, no functional studies have been identified regarding the …
pro-carcinogenic. However, no functional studies have been identified regarding the …
Peptide vaccine from cancer-testis antigen ODF2 can potentiate the cytotoxic T lymphocyte infiltration through IL-15 in non-MSI-H colorectal cancer
R Shi, X Zhou, L Pang, M Wang, Y Li, C Chen… - Cancer Immunology …, 2023 - Springer
About 85% of patients with colorectal cancer (CRC) have the non-microsatellite instability-
high (non-MSI-H) subtype, and many cannot benefit from immune checkpoint blockade. A …
high (non-MSI-H) subtype, and many cannot benefit from immune checkpoint blockade. A …
[HTML][HTML] Effect of metabolism on the immune microenvironment of breast cancer
Y Zhou, H Wang, Y Luo, B Tuo, X Liu, T Li - Biochimica et Biophysica Acta …, 2023 - Elsevier
Breast cancer (BC) is a highly prevalent primary malignancy worldwide with poor prognosis.
Despite the development of aggressive interventions, mortality due to BC remains high. BC …
Despite the development of aggressive interventions, mortality due to BC remains high. BC …
Characterization of the microenvironment in different immune-metabolism subtypes of cervical cancer with prognostic significance
W Lai, J Liao, X Li, P Liang, L He, K Huang… - Frontiers in …, 2023 - frontiersin.org
Introduction: Immune cell infiltration and metabolic reprogramming may have great impact
on the tumorigenesis and progression of malignancies. The interaction between these two …
on the tumorigenesis and progression of malignancies. The interaction between these two …
Cancer-testis antigen lactate dehydrogenase C4 as a novel biomarker of male infertility and cancer
J Wu, Y Chen, Y Lin, F Lan, Z Cui - Frontiers in Oncology, 2022 - frontiersin.org
A unique lactate dehydrogenase (LDH) isoenzyme designated as lactate dehydrogenase
C4 (LDH-C4) is found in mammalian mature testis and spermatozoa. Thus far, LDH-C4 has …
C4 (LDH-C4) is found in mammalian mature testis and spermatozoa. Thus far, LDH-C4 has …