Targeting T-cell metabolism to boost immune checkpoint inhibitor therapy

H Li, A Zhao, M Li, L Shi, Q Han, Z Hou - Frontiers in immunology, 2022 - frontiersin.org
Immune checkpoint inhibitors (ICIs) have shown promising therapeutic effects in the
treatment of advanced solid cancers, but their overall response rate is still very low for …

Lactate metabolism and immune modulation in breast cancer: a focused review on triple negative breast tumors

A Naik, J Decock - Frontiers in Oncology, 2020 - frontiersin.org
Triple negative breast cancer (TNBC) is an aggressive subtype of breast cancer associated
with poor prognosis, early recurrence, and the lack of durable chemotherapy responses and …

Lactate Dehydrogenase A or B Knockdown Reduces Lactate Production and Inhibits Breast Cancer Cell Motility in vitro

MA Khajah, S Khushaish, YA Luqmani - Frontiers in Pharmacology, 2021 - frontiersin.org
Background: Lactate dehydrogenase (LDH) plays an important role in cancer pathogenesis
and enhanced expression/activity of this enzyme has been correlated with poor prognosis …

The role of metabolic reprogramming in immune escape of triple-negative breast cancer

R Bao, H Qu, B Li, K Cheng, Y Miao… - Frontiers in …, 2024 - frontiersin.org
Triple-negative breast cancer (TNBC) has become a thorny problem in the treatment of
breast cancer because of its high invasiveness, metastasis and recurrence. Although …

[HTML][HTML] Sperm proteins and cancer‐testis antigens are released by the seminiferous tubules in mice and men

L O'Donnell, D Rebourcet, LF Dagley, R Sgaier… - The FASEB …, 2021 - ncbi.nlm.nih.gov
Sperm develop from puberty in the seminiferous tubules, inside the blood‐testis barrier to
prevent their recognition as “non‐self” by the immune system, and it is widely assumed that …

FANCA promotes lung adenocarcinoma progression and is a potential target for epitope vaccine immunotherapy

Y Kang, R Zhong, Y Gan, J You, J Chen, F Chen… - Journal of Translational …, 2024 - Springer
Background FANCA mutations have been detected in a variety of cancers and found to be
pro-carcinogenic. However, no functional studies have been identified regarding the …

Peptide vaccine from cancer-testis antigen ODF2 can potentiate the cytotoxic T lymphocyte infiltration through IL-15 in non-MSI-H colorectal cancer

R Shi, X Zhou, L Pang, M Wang, Y Li, C Chen… - Cancer Immunology …, 2023 - Springer
About 85% of patients with colorectal cancer (CRC) have the non-microsatellite instability-
high (non-MSI-H) subtype, and many cannot benefit from immune checkpoint blockade. A …

[HTML][HTML] Effect of metabolism on the immune microenvironment of breast cancer

Y Zhou, H Wang, Y Luo, B Tuo, X Liu, T Li - Biochimica et Biophysica Acta …, 2023 - Elsevier
Breast cancer (BC) is a highly prevalent primary malignancy worldwide with poor prognosis.
Despite the development of aggressive interventions, mortality due to BC remains high. BC …

Characterization of the microenvironment in different immune-metabolism subtypes of cervical cancer with prognostic significance

W Lai, J Liao, X Li, P Liang, L He, K Huang… - Frontiers in …, 2023 - frontiersin.org
Introduction: Immune cell infiltration and metabolic reprogramming may have great impact
on the tumorigenesis and progression of malignancies. The interaction between these two …

Cancer-testis antigen lactate dehydrogenase C4 as a novel biomarker of male infertility and cancer

J Wu, Y Chen, Y Lin, F Lan, Z Cui - Frontiers in Oncology, 2022 - frontiersin.org
A unique lactate dehydrogenase (LDH) isoenzyme designated as lactate dehydrogenase
C4 (LDH-C4) is found in mammalian mature testis and spermatozoa. Thus far, LDH-C4 has …