Dopamine receptor subtypes, physiology and pharmacology: new ligands and concepts in schizophrenia
JC Martel, S Gatti McArthur - Frontiers in pharmacology, 2020 - frontiersin.org
Dopamine receptors are widely distributed within the brain where they play critical
modulator roles on motor functions, motivation and drive, as well as cognition. The …
modulator roles on motor functions, motivation and drive, as well as cognition. The …
[HTML][HTML] Homology modeling a fast tool for drug discovery: current perspectives
VK Vyas, RD Ukawala, M Ghate… - Indian journal of …, 2012 - ncbi.nlm.nih.gov
Major goal of structural biology involve formation of protein-ligand complexes; in which the
protein molecules act energetically in the course of binding. Therefore, perceptive of protein …
protein molecules act energetically in the course of binding. Therefore, perceptive of protein …
Structural basis of efficacy-driven ligand selectivity at GPCRs
A drug's selectivity for target receptors is essential to its therapeutic utility, but achieving
selectivity between similar receptors is challenging. The serendipitous discovery of ligands …
selectivity between similar receptors is challenging. The serendipitous discovery of ligands …
Current drug treatments targeting dopamine D3 receptor
Dopamine receptors (DR) have been extensively studied, but only in recent years they
became object of investigation to elucidate the specific role of different subtypes (D1R, D2R …
became object of investigation to elucidate the specific role of different subtypes (D1R, D2R …
Artificial intelligence and machine-learning approaches in structure and ligand-based discovery of drugs affecting central nervous system
CNS disorders are indications with a very high unmet medical needs, relatively smaller
number of available drugs, and a subpar satisfaction level among patients and caregiver …
number of available drugs, and a subpar satisfaction level among patients and caregiver …
Computational chemistry for the identification of lead compounds for radiotracer development
The use of computer-aided drug design (CADD) for the identification of lead compounds in
radiotracer development is steadily increasing. Traditional CADD methods, such as structure …
radiotracer development is steadily increasing. Traditional CADD methods, such as structure …
From laptop to benchtop to bedside: structure-based drug design on protein targets
As an important aspect of computer-aided drug design, structure-based drug design brought
a new horizon to pharmaceutical development. This in silico method permeates all aspects …
a new horizon to pharmaceutical development. This in silico method permeates all aspects …
Homology modeling: an important tool for the drug discovery
TCC França - Journal of Biomolecular Structure and Dynamics, 2015 - Taylor & Francis
In the last decades, homology modeling has become a popular tool to access theoretical
three-dimensional (3D) structures of molecular targets. So far several 3D models of proteins …
three-dimensional (3D) structures of molecular targets. So far several 3D models of proteins …
Algorithms for structure comparison and analysis: Homology modelling of proteins
M Wiltgen - … of bioinformatics and computational biology: ABC of …, 2018 - books.google.com
Protein structure is uniquely determined by its amino acid sequence. Knowledge of protein
3D structure is of crucial importance for understanding protein function, dynamics and …
3D structure is of crucial importance for understanding protein function, dynamics and …
Targeting the dopamine D3 receptor: an overview of drug design strategies
Introduction: Dopamine is a neurotransmitter widely distributed in both the periphery and the
central nervous system (CNS). Its physiological effects are mediated by five closely related G …
central nervous system (CNS). Its physiological effects are mediated by five closely related G …