Protein-protein interactions (PPIs) mediate a variety of cellular processes and form complex
networks, where connectivity is achieved owing to the “hub” proteins whose interaction with …

UV resonance Raman (UVRR) spectroscopy is a powerful tool for investigating the structure
of biological molecules, such as proteins. Numerous UVRR spectroscopic markers that …

Despite intense efforts, the cause of Alzheimer's disease is still not fully understood. A
chemical and biochemical perspective could shed light on this disorder. Secondary …

Polyglutamine (polyQ) repeat-containing proteins are widespread in the human proteome
but only nine of them are associated with highly incapacitating neurodegenerative disorders …

The conformational ensembles of a disordered peptide, polyglutamine Q15, over a wide
temperature range were sampled using multiple replicates of conventional molecular …

We determined an empirical correlation that relates the amide I vibrational band frequencies
of the glutamine (Q) side chain to the strength of hydrogen bonding, van der Waals, and …

We present structural models for three different amyloid fibril polymorphs prepared from
amylin 20–29 (sequence SNNFGAILSS) and amyloid-β 25–35 (Aβ 25–35)(sequence …

Expanded polyglutamine (polyQ) sequences cause numerous neurodegenerative diseases
which are accompanied by the formation of polyQ fibrils. The unique role of glutamines in …

Fibrillization of polyglutamine (polyQ) tracts in proteins is implicated in at least 10
neurodegenerative diseases. This generates great interest in the structure and the …

Polyglutamine (polyQ) disorders are a group of neurodegenerative diseases characterized
by the excessive expansion of CAG (cytosine, adenine, guanine) repeats within host …