Brain-derived neurotrophic factor (BDNF) promotes neuroprotection and neuroregeneration.
In animal models of Parkinson's disease (PD), BDNF enhances the survival of dopaminergic …

It is well known that brain-derived neurotrophic factor, BDNF, has an important role in a
variety of neuronal aspects, such as differentiation, maturation, and synaptic function in the …

Parkinson's disease (PD) is characterized by intracellular inclusions of aggregated and
misfolded α-Synuclein (α-Syn), and the loss of dopaminergic (DA) neurons in the brain. The …

It has been 200 years since Parkinson disease (PD) was described by Dr. Parkinson in
1817. The disease is the second most common neurodegenerative disease characterized …

Abstract The endosome-associated GTPase Rab5 is a central player in the molecular
mechanisms leading to degeneration of basal forebrain cholinergic neurons (BFCN), a long …

Epilepsy is a neurological disease characterized by repeated seizures. Despite of that the
brain-derived neurotrophic factor (BDNF) is implicated in the pathogenesis of …

Parkinson's disease (PD) is a neurodegenerative disorder of the brain and is manifested by
motor and non‐motor symptoms because of degenerative changes in dopaminergic …

Neuronal endosomal dysfunction, the earliest known pathobiology specific to Alzheimer's
disease (AD), is mediated by the aberrant activation of Rab5 triggered by APP-β secretase …

Huntington's disease (HD) is caused by an expanded CAG repeat in the huntingtin gene,
yielding a Huntingtin protein with an expanded polyglutamine tract. While experiments with …

LRRK2 has been implicated in endolysosomal function and likely plays a central role in
idiopathic Parkinson's disease (iPD). In iPD, dopaminergic neurons within the substantia …