Background and Objectives Cluster headache and migraine have circadian features at
multiple levels (cellular, systems, and behavioral). A thorough understanding of their …

Cluster headache and migraine are regarded as distinct primary headaches. While cluster
headache and migraine differ in multiple aspects such as gender-related and headache …

Objective In this narrative review, we summarize clinical and experimental data on the effect
of light in migraine and discuss future prospects. Background Effective nonpharmacological …

Intelligent digital twins closely resemble their real-life counterparts. In health and medical
care, they enable the real-time monitoring of patients, whereby large amounts of data can be …

Mechanisms underlying the migraine aura are incompletely understood, which to large
extent is related to a lack of models in which cortical spreading depolarization (CSD), the …

Background Limited epidemiological data are available for headache disorders in Japan,
and no recent studies have reported the impact of several primary headache disorders in …

Background In recent years, innovative approaches utilizing Internet data have emerged in
the field of syndromic surveillance. These novel methods aim to aid in the early prediction of …

Objective The evaluation of patients with headache relies heavily on the history. This article
reviews key questions for diagnosing primary and secondary headache disorders with a …

Background There is an unmet need for a better understanding and management of
headache, particularly migraine, beyond specialist centers, which may be facilitated using …

Chronobiology is a multidisciplinary field that extends across the tree of life, transcends all
scales of biological organization, and has huge translational potential. For the UK to harness …