Ion channels as lipid sensors: from structures to mechanisms
Ion channels play critical roles in cellular function by facilitating the flow of ions across the
membrane in response to chemical or mechanical stimuli. Ion channels operate in a lipid …
membrane in response to chemical or mechanical stimuli. Ion channels operate in a lipid …
Pro-arrhythmic effects of gain-of-function potassium channel mutations in the short QT syndrome
The congenital short QT syndrome (SQTS) is a rare condition characterized by abbreviated
rate-corrected QT (QTc) intervals on the electrocardiogram and by increased susceptibility to …
rate-corrected QT (QTc) intervals on the electrocardiogram and by increased susceptibility to …
Structure of human Cav2.2 channel blocked by the painkiller ziconotide
The neuronal-type (N-type) voltage-gated calcium (Cav) channels, which are designated
Cav2. 2, have an important role in the release of neurotransmitters,–. Ziconotide is a Cav2. 2 …
Cav2. 2, have an important role in the release of neurotransmitters,–. Ziconotide is a Cav2. 2 …
Molecular basis for ligand activation of the human KCNQ2 channel
X Li, Q Zhang, P Guo, J Fu, L Mei, D Lv, J Wang, D Lai… - Cell research, 2021 - nature.com
The voltage-gated potassium channel KCNQ2 is responsible for M-current in neurons and is
an important drug target to treat epilepsy, pain and several other diseases related to …
an important drug target to treat epilepsy, pain and several other diseases related to …
The membrane electric field regulates the PIP2-binding site to gate the KCNQ1 channel
VS Mandala, R MacKinnon - Proceedings of the National …, 2023 - National Acad Sciences
Voltage-dependent ion channels underlie the propagation of action potentials and other
forms of electrical activity in cells. In these proteins, voltage sensor domains (VSDs) regulate …
forms of electrical activity in cells. In these proteins, voltage sensor domains (VSDs) regulate …
Human IFT-A complex structures provide molecular insights into ciliary transport
M Jiang, VR Palicharla, D Miller, SH Hwang, H Zhu… - Cell Research, 2023 - nature.com
Intraflagellar transport (IFT) complexes, IFT-A and IFT-B, form bidirectional trains that move
along the axonemal microtubules and are essential for assembling and maintaining cilia …
along the axonemal microtubules and are essential for assembling and maintaining cilia …
[HTML][HTML] Structural basis of gating modulation of Kv4 channel complexes
Modulation of voltage-gated potassium (Kv) channels by auxiliary subunits is central to the
physiological function of channels in the brain and heart,. Native Kv4 tetrameric channels …
physiological function of channels in the brain and heart,. Native Kv4 tetrameric channels …
Conformational motions and ligand-binding underlying gating and regulation in IP3R channel
Abstract Inositol-1, 4, 5-trisphosphate receptors (IP3Rs) are activated by IP3 and Ca2+ and
their gating is regulated by various intracellular messengers that finely tune the channel …
their gating is regulated by various intracellular messengers that finely tune the channel …
Ligand activation mechanisms of human KCNQ2 channel
D Ma, Y Zheng, X Li, X Zhou, Z Yang, Y Zhang… - Nature …, 2023 - nature.com
The human voltage-gated potassium channel KCNQ2/KCNQ3 carries the neuronal M-
current, which helps to stabilize the membrane potential. KCNQ2 can be activated by …
current, which helps to stabilize the membrane potential. KCNQ2 can be activated by …
Structural basis for the modulation of human KCNQ4 by small-molecule drugs
T Li, K Wu, Z Yue, Y Wang, F Zhang, H Shen - Molecular Cell, 2021 - cell.com
Among the five KCNQ channels, also known as the K v 7 voltage-gated potassium (K v)
channels, KCNQ2–KCNQ5 control neuronal excitability. Dysfunctions of KCNQ2–KCNQ5 …
channels, KCNQ2–KCNQ5 control neuronal excitability. Dysfunctions of KCNQ2–KCNQ5 …