Rescuing the last-line polymyxins: achievements and challenges
Antibiotic resistance is a major global health challenge and, worryingly, several key Gram
negative pathogens can become resistant to most currently available antibiotics. Polymyxins …
negative pathogens can become resistant to most currently available antibiotics. Polymyxins …
The gut microbiome's role in the development, maintenance, and outcomes of sepsis
MW Adelman, MH Woodworth, C Langelier, LM Busch… - Critical care, 2020 - Springer
The gut microbiome regulates a number of homeostatic mechanisms in the healthy host
including immune function and gut barrier protection. Loss of normal gut microbial structure …
including immune function and gut barrier protection. Loss of normal gut microbial structure …
International ERS/ESICM/ESCMID/ALAT guidelines for the management of hospital-acquired pneumonia and ventilator-associated pneumonia: Guidelines for the …
The most recent European guidelines and task force reports on hospital-acquired
pneumonia (HAP) and ventilator-associated pneumonia (VAP) were published almost 10 …
pneumonia (HAP) and ventilator-associated pneumonia (VAP) were published almost 10 …
Association between selective decontamination of the digestive tract and in-hospital mortality in intensive care unit patients receiving mechanical ventilation: a …
Importance The effectiveness of selective decontamination of the digestive tract (SDD) in
critically ill adults receiving mechanical ventilation is uncertain. Objective To determine …
critically ill adults receiving mechanical ventilation is uncertain. Objective To determine …
Bacterial and fungal infections in acute-on-chronic liver failure: prevalence, characteristics and impact on prognosis
Bacterial infection is a frequent trigger of acute-on-chronic liver failure (ACLF), syndrome
that could also increase the risk of infection. This investigation evaluated prevalence and …
that could also increase the risk of infection. This investigation evaluated prevalence and …
Incidence, risk factors, and attributable mortality of secondary infections in the intensive care unit after admission for sepsis
LA van Vught, PMCK Klouwenberg, C Spitoni… - Jama, 2016 - jamanetwork.com
Importance Sepsis is considered to induce immune suppression, leading to increased
susceptibility to secondary infections with associated late mortality. Objective To determine …
susceptibility to secondary infections with associated late mortality. Objective To determine …
Mechanisms of antimicrobial resistance in Gram-negative bacilli
É Ruppé, PL Woerther, F Barbier - Annals of intensive care, 2015 - Springer
The burden of multidrug resistance in Gram-negative bacilli (GNB) now represents a daily
issue for the management of antimicrobial therapy in intensive care unit (ICU) patients. In …
issue for the management of antimicrobial therapy in intensive care unit (ICU) patients. In …
Strategies to prevent ventilator-associated pneumonia in acute care hospitals: 2014 update
Previously published guidelines are available that provide comprehensive
recommendations for detecting and preventing healthcare-associated infections (HAIs). The …
recommendations for detecting and preventing healthcare-associated infections (HAIs). The …
Surviving sepsis campaign: international guidelines for management of severe sepsis and septic shock: 2012
Objective: To provide an update to the “Surviving Sepsis Campaign Guidelines for
Management of Severe Sepsis and Septic Shock,” last published in 2008. Design: A …
Management of Severe Sepsis and Septic Shock,” last published in 2008. Design: A …