Nanopore direct RNA sequencing maps the complexity of Arabidopsis mRNA processing and m6A modification
Understanding genome organization and gene regulation requires insight into RNA
transcription, processing and modification. We adapted nanopore direct RNA sequencing to …
transcription, processing and modification. We adapted nanopore direct RNA sequencing to …
In situ organic biosignature detection techniques for space applications
The search for life in Solar System bodies such as Mars and Ocean Worlds (eg, Europa and
Enceladus) is an ongoing and high-priority endeavor in space science, even∼ five decades …
Enceladus) is an ongoing and high-priority endeavor in space science, even∼ five decades …
Relative performance of MinION (Oxford Nanopore Technologies) versus Sequel (Pacific Biosciences) third-generation sequencing instruments in identification of …
Culture-based molecular identification methods have revolutionized detection of pathogens,
yet these methods are slow and may yield inconclusive results from environmental …
yet these methods are slow and may yield inconclusive results from environmental …
Subsurface science and search for life in ocean worlds
Several worlds in our solar system are thought to hold oceans of liquid water beneath their
frozen surfaces. These subsurface ice and ocean environments are promising targets in the …
frozen surfaces. These subsurface ice and ocean environments are promising targets in the …
Enceladus as a potential oasis for life: Science goals and investigations for future explorations
Enceladus is the first planetary object for which direct sampling of a subsurface water
reservoir, likely habitable, has been performed. Over a decade of flybys and seven …
reservoir, likely habitable, has been performed. Over a decade of flybys and seven …
The limits, capabilities, and potential for life detection with MinION sequencing in a Paleochannel Mars analog
No instrument capable of direct life detection has been included on a mission payload to
Mars since NASA's Viking missions in the 1970s. This prevents us from discovering whether …
Mars since NASA's Viking missions in the 1970s. This prevents us from discovering whether …
Nucleic Acid Extraction and Sequencing from Low-Biomass Synthetic Mars Analog Soils for In Situ Life Detection
A Mojarro, J Hachey, R Bailey, M Brown, R Doebler… - Astrobiology, 2019 - liebertpub.com
Recent studies regarding the origins of life and Mars-Earth meteorite transfer simulations
suggest that biological informational polymers, such as nucleic acids (DNA and RNA), have …
suggest that biological informational polymers, such as nucleic acids (DNA and RNA), have …
Field-based detection of bacteria using nanopore sequencing: Method evaluation for biothreat detection in complex samples
AD Tyler, J McAllister, H Stapleton, P Gauci… - Plos one, 2023 - journals.plos.org
From pathogen detection to genome or plasmid closure, the utility of the Oxford Nanopore
Technologies (ONT) MinION for microbiological analysis has been well documented. The …
Technologies (ONT) MinION for microbiological analysis has been well documented. The …
Applying Novel Techniques from Physical and Biological Sciences to Life Detection
One of the primary goals of the space exploration community is to unambiguously detect
past or present life outside of Earth. As such, a number of so-called life detection …
past or present life outside of Earth. As such, a number of so-called life detection …
Nucleic acid sequencing under Mars-like conditions
All known life uses informational polymers based on nucleic acids. Future missions to Mars
and Ocean Worlds such as Enceladus and/or Europa may target these or related polymers …
and Ocean Worlds such as Enceladus and/or Europa may target these or related polymers …