Inflammation and immune mechanisms are crucially involved in the pathophysiology of the
development, acute damage cascades, and chronic course after ischemic stroke …

Background: Several studies suggested an important role of the gut microbiota in the
pathophysiology of neurological disorders, implying that alteration of the gut microbiota …

Trauma can affect any individual at any location and at any time over a lifespan. The
disruption of macrobarriers and microbarriers induces instant activation of innate immunity …

Spinal cord injury can lead to severe motor, sensory and autonomic dysfunction. Currently,
there is no effective treatment for the injured spinal cord. The transplantation of Schwann …

Traumatic brain injury (TBI) is a chronic and progressive disease, and management requires
an understanding of both the primary neurological injury and the secondary sequelae that …

Understanding the relationship between infection and stroke has taken on new urgency in
the era of the coronavirus disease 2019 (COVID-19) pandemic. This association is not a …

The immune response to acute cerebral ischemia is a major factor in stroke pathobiology
and outcome. While the immune response starts locally in occluded and hypoperfused …

Active research at the frontiers of immunology and neuroscience has identified multiple
points of interaction and communication between the immune system and the nervous …

The vast majority of cerebral stroke cases are caused by transient or permanent occlusion of
a cerebral blood vessel (“ischemic stroke”) eventually leading to brain infarction. The final …

The CNS is protected by the immune system, including cells that reside directly within the
CNS and help to ensure proper neural function, as well as cells that traffic into the CNS with …