Mycobacterium tuberculosis (Mtb), the causative agent of Tuberculosis (TB), remains a
pathogen of great interest on a global scale. This airborne pathogen affects the lungs, where …

Caseum, the central necrotic material of tuberculous lesions, is a reservoir of drug-
recalcitrant persisting mycobacteria. Caseum is found in closed nodules and in open …

Ferritin, a key regulator of iron homeostasis in macrophages, has been reported to confer
host defenses against Mycobacterium tuberculosis (Mtb) infection. Nuclear receptor …

The ability of Mycobacterium tuberculosis (Mtb) to persist in the host complicates and
prolongs tuberculosis (TB) patient chemotherapy. Here we demonstrate that a neglected two …

Iron is essential for nearly all bacterial pathogens, including Mycobacterium tuberculosis
(Mtb), but is severely limited in the human host. To meet its iron needs, Mtb secretes …

Iron is essential for growth of Mycobacterium tuberculosis (Mtb), but most iron in the human
body is stored in heme within hemoglobin. Here, we demonstrate that the substrate-binding …

Heme biosynthesis in the Gram-positive bacteria occurs mostly via a pathway that is distinct
from that of eukaryotes and Gram-negative bacteria in the three terminal heme synthesis …

Moxifloxacin is central to treatment of multidrug-resistant tuberculosis. Effects of moxifloxacin
on the Mycobacterium tuberculosis redox state were explored to identify strategies for …

Iron-sulfur (Fe-S) biogenesis requires multiprotein assembly systems, SUF and ISC, in most
prokaryotes. M. tuberculosis (Mtb) encodes a complete SUF system, the depletion of which …

Mycobacterium tuberculosis (Mtb), the cause of the human pulmonary disease tuberculosis
(TB), contributes to approximately 1.5 million deaths every year. Prior work has established …