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BRCT domains: structure, functions, and implications in disease—new therapeutic targets for innovative drug discovery against infections
The search for new therapeutic targets and their implications in drug development remains
an emerging scientific topic. BRCT-bearing proteins are found in Archaea, Bacteria …
an emerging scientific topic. BRCT-bearing proteins are found in Archaea, Bacteria …
Generating and repairing genetically programmed DNA breaks during immunoglobulin class switch recombination
L Nicolas, M Cols, JE Choi, J Chaudhuri… - …, 2018 - pmc.ncbi.nlm.nih.gov
Adaptive immune responses require the generation of a diverse repertoire of
immunoglobulins (Igs) that can recognize and neutralize a seemingly infinite number of …
immunoglobulins (Igs) that can recognize and neutralize a seemingly infinite number of …
Microcephalin 1/BRIT1-TRF2 interaction promotes telomere replication and repair, linking telomere dysfunction to primary microcephaly
A Cicconi, R Rai, X **ong, C Broton… - Nature …, 2020 - nature.com
Telomeres protect chromosome ends from inappropriately activating the DNA damage and
repair responses. Primary microcephaly is a key clinical feature of several human telomere …
repair responses. Primary microcephaly is a key clinical feature of several human telomere …
Microcephaly family protein MCPH1 stabilizes RAD51 filaments
Abstract Microcephalin 1 (MCPH1) was identified from genetic mutations in patients with
primary autosomal recessive microcephaly. In response to DNA double-strand breaks …
primary autosomal recessive microcephaly. In response to DNA double-strand breaks …
Mechanism and Regulation of Immunoglobulin Class Switch Recombination
FL Meng, L Nair, KC Fernandez, U Basu… - Molecular Biology of B …, 2024 - Elsevier
Class switch recombination (CSR) represents one of the hallmark DNA transactions that
activated B cells execute during the generation of a humoral immune response to diversify …
activated B cells execute during the generation of a humoral immune response to diversify …
Mécanismes moléculaires impliqués lors de la commutation isotypique
M Rogier - 2020 - theses.hal.science
Au cours des réponses immunes, le répertoire des cellules B est diversifié par
l'hypermutation somatique (HMS) et la commutation isotypique (CI). Ces mécanismes sont …
l'hypermutation somatique (HMS) et la commutation isotypique (CI). Ces mécanismes sont …