BRCT domains: structure, functions, and implications in disease—new therapeutic targets for innovative drug discovery against infections

J Peña-Guerrero, C Fernández-Rubio, AT García-Sosa… - Pharmaceutics, 2023 - mdpi.com
The search for new therapeutic targets and their implications in drug development remains
an emerging scientific topic. BRCT-bearing proteins are found in Archaea, Bacteria …

Generating and repairing genetically programmed DNA breaks during immunoglobulin class switch recombination

L Nicolas, M Cols, JE Choi, J Chaudhuri… - …, 2018 - pmc.ncbi.nlm.nih.gov
Adaptive immune responses require the generation of a diverse repertoire of
immunoglobulins (Igs) that can recognize and neutralize a seemingly infinite number of …

Microcephalin 1/BRIT1-TRF2 interaction promotes telomere replication and repair, linking telomere dysfunction to primary microcephaly

A Cicconi, R Rai, X **ong, C Broton… - Nature …, 2020 - nature.com
Telomeres protect chromosome ends from inappropriately activating the DNA damage and
repair responses. Primary microcephaly is a key clinical feature of several human telomere …

Microcephaly family protein MCPH1 stabilizes RAD51 filaments

HY Chang, CY Lee, CH Lu, W Lee… - Nucleic Acids …, 2020 - academic.oup.com
Abstract Microcephalin 1 (MCPH1) was identified from genetic mutations in patients with
primary autosomal recessive microcephaly. In response to DNA double-strand breaks …

Mechanism and Regulation of Immunoglobulin Class Switch Recombination

FL Meng, L Nair, KC Fernandez, U Basu… - Molecular Biology of B …, 2024 - Elsevier
Class switch recombination (CSR) represents one of the hallmark DNA transactions that
activated B cells execute during the generation of a humoral immune response to diversify …

Mécanismes moléculaires impliqués lors de la commutation isotypique

M Rogier - 2020 - theses.hal.science
Au cours des réponses immunes, le répertoire des cellules B est diversifié par
l'hypermutation somatique (HMS) et la commutation isotypique (CI). Ces mécanismes sont …