Biocatalysis has revolutionized chemical synthesis, providing sustainable methods for
preparing various organic molecules. In enzyme-mediated organic synthesis, most reactions …

Biocatalysis, using defined enzymes for organic transformations, has become a common
tool in organic synthesis, which is also frequently applied in industry. The generally high …

Exploiting nature's catalysts for non-natural transformations that are inaccessible to
chemocatalysis is highly desirable but challenging. On the one hand, the widespread …

Enzymes are ideal for use in asymmetric catalysis by the chemical industry, because their
chemical compositions can be tailored to a specific substrate and selectivity pattern while …

A highly enantioselective biocatalytic dynamic kinetic resolution (DKR) of configurationally
labile N-arylindole aldehydes is described. The DKR proceeds by atroposelective …

The free energy landscape concept that describes enzymes as an ensemble of differently
populated conformational sub-states in dynamic equilibrium is key for evaluating enzyme …

Recently, there has been an increase in the demand for enzymes with modified activity,
specificity, and stability. Enzyme engineering is an important tool to meet the demand for …

Protein engineering is a powerful strategy for enhancing the properties of enzymes for
industrial applications. However, thermostabilizing an enzyme via this strategy while …

Catalytic asymmetric dearomatization represents a powerful means to convert flat aromatic
compounds into stereochemically well-defined three-dimensional molecular scaffolds. Using …

Enzymes, at the turn of the 21st century, are gaining a momentum. Especially in the field of
synthetic organic chemistry, a broad variety of biocatalysts are being applied in an …