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[HTML][HTML] Organotypic brain slice cultures: A review
C Humpel - Neuroscience, 2015 - Elsevier
In vitro cell cultures are an important tool for obtaining insights into cellular processes in an
isolated system and a supplement to in vivo animal experiments. While primary dissociated …
isolated system and a supplement to in vivo animal experiments. While primary dissociated …
Blood–brain barrier structure and function and the challenges for CNS drug delivery
NJ Abbott - Journal of inherited metabolic disease, 2013 - Springer
The neurons of the central nervous system (CNS) require precise control of their bathing
microenvironment for optimal function, and an important element in this control is the blood …
microenvironment for optimal function, and an important element in this control is the blood …
The neurovascular unit–concept review
V Muoio, PB Persson, MM Sendeski - Acta physiologica, 2014 - Wiley Online Library
The cerebral hyperaemia is one of the fundamental mechanisms for the central nervous
system homeostasis. Due also to this mechanism, oxygen and nutrients are maintained in …
system homeostasis. Due also to this mechanism, oxygen and nutrients are maintained in …
IFNγ-stimulated dendritic cell exosomes as a potential therapeutic for remyelination
Dendritic cells (DCs) release exosomes with different characteristics based on stimulus.
Here, we showed that DC cultures stimulated with low-level IFNγ released exosomes (IFNγ …
Here, we showed that DC cultures stimulated with low-level IFNγ released exosomes (IFNγ …
Seizure‐induced microvascular injury is associated with impaired neurovascular coupling and blood–brain barrier dysfunction
O Prager, L Kamintsky, LA Hasam‐Henderson… - …, 2019 - Wiley Online Library
Objective Blood–brain barrier (BBB) impairment, redistribution of pericytes, and
disturbances in cerebral blood flow may contribute to the increased seizure propensity and …
disturbances in cerebral blood flow may contribute to the increased seizure propensity and …
Extensive astrocyte synchronization advances neuronal coupling in slow wave activity in vivo
Slow wave activity (SWA) is a characteristic brain oscillation in sleep and quiet wakefulness.
Although the cell types contributing to SWA genesis are not yet identified, the principal role …
Although the cell types contributing to SWA genesis are not yet identified, the principal role …
Mechanisms underlying blood–brain barrier dysfunction in brain pathology and epileptogenesis: Role of astroglia
Astrocytes are increasingly recognized as equal partners to neurons, also contributing to
neurologic disorders such as epilepsy. Activated astrocytes are a common hallmark in …
neurologic disorders such as epilepsy. Activated astrocytes are a common hallmark in …
Spreading depression requires microglia and is decreased by their M2a polarization from environmental enrichment
KM Pusic, AD Pusic, J Kemme, RP Kraig - Glia, 2014 - Wiley Online Library
Microglia play an important role in fine‐tuning neuronal activity. In part, this involves their
production of tumor necrosis factor‐alpha (TNFα), which increases neuronal excitability …
production of tumor necrosis factor‐alpha (TNFα), which increases neuronal excitability …
Organotypic hippocampal slice culture from the adult mouse brain: a versatile tool for translational neuropsychopharmacology
One of the most significant barriers towards translational neuropsychiatry would be an
unavailability of living brain tissues. Although organotypic brain tissue culture could be a …
unavailability of living brain tissues. Although organotypic brain tissue culture could be a …
Intraventricular haemorrhage in premature infants: the role of immature neuronal salt and water transport
Intraventricular haemorrhage is a common complication of premature birth. Survivors are
often left with cerebral palsy, intellectual disability and/or hydrocephalus. Animal models …
often left with cerebral palsy, intellectual disability and/or hydrocephalus. Animal models …