A hallmark event in neurodegenerative diseases (NDs) is the misfolding, aggregation, and
accumulation of proteins, leading to cellular dysfunction, loss of synaptic connections, and …

Emerging experimental evidence suggests that the spread of tau pathology in the brain in
Tauopathies reflects the propagation of abnormal tau species along neuroanatomically …

The ordered assembly of tau protein into abnormal filamentous inclusions underlies many
human neurodegenerative diseases. Tau assemblies seem to spread through specific …

Tau is a microtubule-associated protein with versatile functions in the dynamic assembly of
the neuronal cytoskeleton. Four-repeat (4R-) tauopathies are a group of neurodegenerative …

Most common neurodegenerative diseases feature deposition of protein amyloids and
degeneration of brain networks. Amyloids are ordered protein assemblies that can act as …

The understanding of neurodegenerative diseases, traditionally considered to be well-
defined entities with distinguishable clinical phenotypes, has undergone a major shift over …

Background Parkinson's disease (PD) is a neurodegenerative disorder whose diagnosis is
often challenging because symptoms may overlap with neurodegenerative parkinsonisms …

Synucleinopathies are a group of neurodegenerative diseases (NDs) associated with
cerebral accumulation of α-synuclein (αSyn) misfolded aggregates. At this time, there is no …

Neuropathological diagnostic criteria of neurodegenerative disorders are based on the
presence of specific inclusions in a specific area of brain tissue that correlate with clinical …

Intracellular accumulation of abnormal proteins with conformational changes is the defining
neuropathological feature of neurodegenerative diseases. The pathogenic proteins that …