Dynamic contrast‐enhanced MRI (DCE‐MRI) is a functional MRI method where T1‐
weighted MR images are acquired dynamically after bolus injection of a contrast agent. The …

Perfusion is a fundamental biological function that refers to the delivery of oxygen and
nutrients to tissue by means of blood flow. Perfusion MRI is sensitive to microvasculature …

Worldwide, stroke is a leading cause of death and disability. Recombinant tissue
plasminogen activator (rtPA) was approved a decade ago for the treatment of acute ischemic …

Relative cerebral blood flow (CBF) and tissue mean transit time (MTT) estimates from bolus‐
tracking MR perfusion‐weighted imaging (PWI) have been shown to be sensitive to delay …

Stroke is a leading cause of mortality and morbidity in the developed world. The goals of an
imaging evaluation for acute stroke are to establish a diagnosis as early as possible and to …

Numerous techniques have been proposed in the last 15 years to measure various
perfusion‐related parameters in the brain. In particular, two approaches have proven …

CT perfusion (CTP) is a functional imaging technique that provides important information
about capillary-level hemodynamics of the brain parenchyma and is a natural complement …

The principles of cerebral perfusion imaging by the method of dynamic susceptibility contrast
magnetic resonance imaging (DSC‐MRI)(bolus tracking) are described. The MRI signals …

The acetazolamide (ACZ) challenge test is a useful clinical tool and a reliable predictor of
critically reduced perfusion. In patients with chronic steno-occlusive disease, the ability to …

Tracer kinetic methods employed for quantitative analysis of dynamic contrast‐enhanced
(DCE) magnetic resonance imaging (MRI) share common roots with earlier tracer studies …