The persistent dilemma of microbial keratitis: Global burden, diagnosis, and antimicrobial resistance

L Ung, PJM Bispo, SS Shanbhag, MS Gilmore… - Survey of …, 2019 - Elsevier
Microbial keratitis is a potentially blinding condition that must be treated emergently to
preserve vision. Although long recognized as a significant cause of corneal blindness, our …

[HTML][HTML] Application of next generation sequencing in laboratory medicine

Y Zhong, F Xu, J Wu, J Schubert… - Annals of laboratory …, 2021 - synapse.koreamed.org
The rapid development of next-generation sequencing (NGS) technology, including
advances in sequencing chemistry, sequencing technologies, bioinformatics, and data …

Major data analysis errors invalidate cancer microbiome findings

A Gihawi, Y Ge, J Lu, D Puiu, A Xu, CS Cooper… - MBio, 2023 - Am Soc Microbiol
We re-analyzed the data from a recent large-scale study that reported strong correlations
between DNA signatures of microbial organisms and 33 different cancer types and that …

Metagenome analysis using the Kraken software suite

J Lu, N Rincon, DE Wood, FP Breitwieser… - Nature protocols, 2022 - nature.com
Metagenomic experiments expose the wide range of microscopic organisms in any
microbial environment through high-throughput DNA sequencing. The computational …

Fungal keratitis: An overview of clinical and laboratory aspects

S Mahmoudi, A Masoomi, K Ahmadikia… - Mycoses, 2018 - Wiley Online Library
Mycotic keratitis or keratomycosis is a fungal infection with global distribution. The dominant
aetiology of this disease varies based on geographical origin, socioeconomic status, and …

[HTML][HTML] The global epidemiology and clinical diagnosis of Acanthamoeba keratitis

Y Zhang, X Xu, Z Wei, K Cao, Z Zhang… - Journal of Infection and …, 2023 - Elsevier
Acanthamoeba keratitis is a rare parasitic infection of the cornea that can lead to permanent
blindness if not diagnosed and treated promptly. We collected data on the incidences of …

Bacterial keratitis: identifying the areas of clinical uncertainty

S Tuft, TF Somerville, JPO Li, T Neal, S De… - Progress in retinal and …, 2022 - Elsevier
Bacterial keratitis is a common corneal infection that is treated with topical antimicrobials. By
the time of presentation there may already be severe visual loss from corneal ulceration and …

[HTML][HTML] Diagnostic armamentarium of infectious keratitis: A comprehensive review

DSJ Ting, BP Gopal, R Deshmukh, GD Seitzman… - The Ocular Surface, 2022 - Elsevier
Infectious keratitis (IK) represents the leading cause of corneal blindness worldwide,
particularly in develo** countries. A good outcome of IK is contingent upon timely and …

Next-generation sequencing in clinical microbiology: are we there yet?

SL Mitchell, PJ Simner - Clinics in laboratory medicine, 2019 - labmed.theclinics.com
Next-generation sequencing (NGS) is a method that allows for high-throughput, massively
parallel sequencing of thousands to billions of DNA fragments independently and …

The role of fungi in fungal keratitis

B Mills, N Radhakrishnan, SGK Rajapandian… - Experimental Eye …, 2021 - Elsevier
Fungal keratitis (FK) accounts for approximately half of the microbial keratitis encountered in
low middle income countries (LMICs) and predominantly affect the working rural-poor. FK …