The multifaceted roles of GSDME-mediated pyroptosis in cancer: therapeutic strategies and persisting obstacles
Y Hu, Y Liu, L Zong, W Zhang, R Liu, Q **ng, Z Liu… - Cell death & …, 2023 - nature.com
Pyroptosis is a novel regulated cell death (RCD) mode associated with inflammation and
innate immunity. Gasdermin E (GSDME), a crucial component of the gasdermin (GSDM) …
innate immunity. Gasdermin E (GSDME), a crucial component of the gasdermin (GSDM) …
Crosstalk of pyroptosis and cytokine in the tumor microenvironment: from mechanisms to clinical implication
H Wang, T Wang, S Yan, J Tang, Y Zhang, L Wang… - Molecular Cancer, 2024 - Springer
In the realm of cancer research, the tumor microenvironment (TME) plays a crucial role in
tumor initiation and progression, shaped by complex interactions between cancer cells and …
tumor initiation and progression, shaped by complex interactions between cancer cells and …
Mechanisms and cross-talk of regulated cell death and their epigenetic modifications in tumor progression
R He, Y Liu, W Fu, X He, S Liu, D **ao, Y Tao - Molecular Cancer, 2024 - Springer
Cell death is a fundamental part of life for metazoans. To maintain the balance between cell
proliferation and metabolism of human bodies, a certain number of cells need to be removed …
proliferation and metabolism of human bodies, a certain number of cells need to be removed …
Epigenetic regulation of pyroptosis in cancer: molecular pathogenesis and targeting strategies
RN Zhang, ZQ **g, L Zhang, ZJ Sun - Cancer Letters, 2023 - Elsevier
Immune checkpoint blockade therapy has revolutionized the field of cancer treatment,
leading to durable responses in patients with advanced and metastatic cancers where …
leading to durable responses in patients with advanced and metastatic cancers where …
Regulated cell death in glioma: promising targets for natural small-molecule compounds
M Han, S Li, H Fan, J An, C Peng, F Peng - Frontiers in oncology, 2024 - frontiersin.org
Gliomas are prevalent malignant tumors in adults, which can be categorized as either
localized or diffuse gliomas. Glioblastoma is the most aggressive and deadliest form of …
localized or diffuse gliomas. Glioblastoma is the most aggressive and deadliest form of …
NLRC4, inflammation and colorectal cancer
G Tong, Y Shen, H Li, H Qian… - … Journal of Oncology, 2024 - spandidos-publications.com
Chronic inflammation is recognized as a major risk factor for cancer and is involved in every
phase of the disease. Inflammasomes are central to the inflammatory response and play a …
phase of the disease. Inflammasomes are central to the inflammatory response and play a …
EZH2–STAT3 signaling pathway regulates GSDMD-mediated pyroptosis in glioblastoma
D Yu, S Wang, J Wang, K Zhang, Z Niu, N Lin - Cell Death Discovery, 2024 - nature.com
Glioblastoma multiforme (GBM) is the most therapeutically challenging primary brain tumor
owing to the unique physiological structure of the blood–brain barrier. Lately, research on …
owing to the unique physiological structure of the blood–brain barrier. Lately, research on …
Gasdermins: a dual role in pyroptosis and tumor immunity
J Yang, J Jiang - Frontiers in immunology, 2024 - frontiersin.org
The gasdermin (GSDM) protein family plays a pivotal role in pyroptosis, a process critical to
the body's immune response, particularly in combatting bacterial infections, impeding tumor …
the body's immune response, particularly in combatting bacterial infections, impeding tumor …
Pyroptosis in glioma: Current management and future application
Z Guo, Z Su, Y Wei, X Zhang, X Hong - Immunological Reviews, 2024 - Wiley Online Library
Glioma, the predominant form of central nervous system (CNS) malignancies, presents a
significant challenge due to its high prevalence and low 5‐year survival rate. The efficacy of …
significant challenge due to its high prevalence and low 5‐year survival rate. The efficacy of …
Emerging prognostic biomarkers in advanced cutaneous melanoma: A literature update
G Roccuzzo, E Bongiovanni, L Tonella… - Expert Review of …, 2024 - Taylor & Francis
Introduction Over the past two years, the scientific community has witnessed an exponential
growth in research focused on identifying prognostic biomarkers for melanoma, both in pre …
growth in research focused on identifying prognostic biomarkers for melanoma, both in pre …