Cholesterol metabolism: A review of how ageing disrupts the biological mechanisms responsible for its regulation

AE Morgan, KM Mooney, SJ Wilkinson, NA Pickles… - Ageing research …, 2016 - Elsevier
Cholesterol plays a vital role in the human body as a precursor of steroid hormones and bile
acids, in addition to providing structure to cell membranes. Whole body cholesterol …

Modelling the molecular mechanisms of aging

MT Mc Auley, AM Guimera, D Hodgson… - Bioscience …, 2017 - portlandpress.com
The aging process is driven at the cellular level by random molecular damage that slowly
accumulates with age. Although cells possess mechanisms to repair or remove damage …

Molecular mechanism of resveratrol and its therapeutic potential on female infertility

R Podgrajsek, H Ban Frangez, M Stimpfel - International Journal of …, 2024 - mdpi.com
Resveratrol is a polyphenol present in various plant sources. Studies have reported
numerous potential health benefits of resveratrol, exhibiting anti-aging, anti-inflammatory …

Divergent aging of isogenic yeast cells revealed through single-cell phenotypic dynamics

M **, Y Li, R O'Laughlin, P Bittihn, L Pillus… - Cell systems, 2019 - cell.com
Although genetic mutations that alter organisms' average lifespans have been identified in
aging research, our understanding of the dynamic changes during aging remains limited …

Understanding the mTOR signaling pathway via mathematical modeling

N Sulaimanov, M Klose, H Busch… - … : Systems Biology and …, 2017 - Wiley Online Library
The mechanistic target of rapamycin (mTOR) is a central regulatory pathway that integrates
a variety of environmental cues to control cellular growth and homeostasis by intricate …

Computational modelling folate metabolism and DNA methylation: implications for understanding health and ageing

MT Mc Auley, KM Mooney… - Briefings in …, 2018 - academic.oup.com
Dietary folates have a key role to play in health, as deficiencies in the intake of these B
vitamins have been implicated in a wide variety of clinical conditions. The reason for this is …

LDL-C levels in older people: cholesterol homeostasis and the free radical theory of ageing converge

MT Mc Auley, KM Mooney - Medical hypotheses, 2017 - Elsevier
The cardiovascular disease (CVD) risk factor, low density lipoprotein cholesterol (LDL-C)
increases with age, up until the midpoint of life in males and females. However, LDL-C can …

Effect of age and lipoperoxidation in rat and human adipose tissue‐derived stem cells

MF Muñoz, S Argüelles, F Marotta… - Oxidative Medicine …, 2020 - Wiley Online Library
A wide range of clinical applications in regenerative medicine were opened decades ago
with the discovery of adult stem cells. Highly promising adult stem cells are mesenchymal …

Aging and computational systems biology

KM Mooney, AE Morgan… - … : Systems Biology and …, 2016 - Wiley Online Library
Aging research is undergoing a paradigm shift, which has led to new and innovative
methods of exploring this complex phenomenon. The systems biology approach endeavors …

Modeling cholesterol metabolism and atherosclerosis

MT Mc Auley - WIREs Mechanisms of Disease, 2022 - Wiley Online Library
Atherosclerotic cardiovascular disease (ASCVD) is the leading cause of morbidity and
mortality among Western populations. Many risk factors have been identified for ASCVD; …