A head-to-head comparison of two DREADD agonists for suppressing operant behavior in rats via VTA dopamine neuron inhibition
Rationale Designer receptors exclusively activated by designer drugs (DREADDs) are a tool
for “remote control” of defined neuronal populations during behavior. These receptors are …
for “remote control” of defined neuronal populations during behavior. These receptors are …
Activation of basal forebrain astrocytes induces wakefulness without compensatory changes in sleep drive
Mammalian sleep is regulated by a homeostatic process that increases sleep drive and
intensity as a function of prior wake time. Sleep homeostasis has traditionally been thought …
intensity as a function of prior wake time. Sleep homeostasis has traditionally been thought …
Multimodal imaging for validation and optimization of ion channel-based chemogenetics in nonhuman primates
Chemogenetic tools provide an opportunity to manipulate neuronal activity and behavior
selectively and repeatedly in nonhuman primates (NHPs) with minimal invasiveness …
selectively and repeatedly in nonhuman primates (NHPs) with minimal invasiveness …
fMRI detects bilateral brain network activation following unilateral chemogenetic activation of direct striatal projection neurons
Y Nakamura, Y Nakamura, A Pelosi, B Djemai… - Neuroimage, 2020 - Elsevier
Abnormal structural and functional connectivity in the striatum during neurological disorders
has been reported using functional magnetic resonance imaging (fMRI), although the effects …
has been reported using functional magnetic resonance imaging (fMRI), although the effects …
Ventral Pallidal GABAergic Neurons Drive Consumption in Male, But Not Female, Rats
A Scott, A Paulson, C Prill, K Kermoade, B Newell… - eneuro, 2025 - eneuro.org
Food intake is controlled by multiple converging signals: hormonal signals that provide
information about energy homeostasis and hedonic and motivational aspects of food and …
information about energy homeostasis and hedonic and motivational aspects of food and …
Disentangling the Neural Circuits of Arousal and Anxiety-Like Behavior
A Florido, VR Curtis, NC Pégard… - 2024 - Springer
Anxiety disorders are prevalent and debilitating conditions characterized by excessive
concern and fear, affecting thoughts, behaviors, and sensations. A critical component of …
concern and fear, affecting thoughts, behaviors, and sensations. A critical component of …
Glucagon-like peptide-1 receptors in the gustatory cortex influence food intake
AM Dossat, MM Kokoska… - Journal of …, 2023 - Soc Neuroscience
The gustatory cortex (GC) region of the insular cortex processes taste information in
manners important for taste-guided behaviors, including food intake itself. In addition to oral …
manners important for taste-guided behaviors, including food intake itself. In addition to oral …
Dual-color optical activation and suppression of neurons with high temporal precision
A well-known phenomenon in the optogenetic toolbox is that all light-gated ion channels,
including red-shifted channelrhodopsins (ChRs), are activated by blue light, whereas blue …
including red-shifted channelrhodopsins (ChRs), are activated by blue light, whereas blue …