Preclinical models (typically ovariectomized rats and genetically altered mice) have
underpinned much of what we know about skeletal biology. They have been pivotal for …

Osteogenesis imperfecta (OI) is a heterogeneous heritable skeletal dysplasia characterized
by bone fragility and deformity, growth deficiency, and other secondary connective tissue …

Osteogenesis imperfecta (OI) is a connective tissue disorder affecting the skeleton and other
organs, which has multiple genetic patterns, numerous causative genes, and complex …

Osteogenesis imperfecta (OI) is a rare congenital bone dysplasia characterized by high
fracture rates and broad variations in clinical manifestations ranging from mild to …

Not much is known about the time course of mineralization in newly formed bone from
healthy individuals nor in patients with bone disease. To investigate the early phase of …

Abstract Purpose of Review Metabolic and genetic bone disorders affect not only bone mass
but often also the bone material, including degree of mineralization, matrix organization, and …

Interferon-inducible transmembrane proteins (IFITMs) are a family of transmembrane
proteins. The subgroup of immunity-related (IR-) IFITMs is involved in adaptive and innate …

Introduction OI type XIV is caused by variants in the TMEM38B gene, encoding for the
ubiquitously expressed endoplasmic reticulum trimeric intracellular cation channel type B …

Many biological fibrous tissues exhibit distinctive mechanical properties arising from their
highly organized fibrous structure. In disease conditions, alterations in the primary …

Osteocytes are mechanosensitive, bone-embedded cells which are connected via dendrites
in a lacuno-canalicular network and regulate bone resorption and formation balance …