The role of lipids in cancer progression and metastasis

M Martin-Perez, U Urdiroz-Urricelqui, C Bigas… - Cell metabolism, 2022 - cell.com
Lipids have essential biological functions in the body (eg, providing energy storage, acting
as a signaling molecule, and being a structural component of membranes); however, an …

Lipids as mediators of cancer progression and metastasis

FCE Vogel, AB Chaves-Filho, A Schulze - Nature cancer, 2024 - nature.com
Metastasis formation is a complex process, involving multiple crucial steps, which are
controlled by different regulatory mechanisms. In this context, the contribution of cancer …

Effects of lead and cadmium combined heavy metals on liver function and lipid metabolism in mice

H Chen, C Zhu, X Zhou - Biological trace element research, 2023 - Springer
Although a large number of studies have been conducted on lead (Pb) and cadmium (Cd)
exposure individually, information regarding the toxicity of combined Pb and Cd exposure is …

Tumor cell metabolic reprogramming and hypoxic immunosuppression: driving carcinogenesis to metastatic colonization

T Katopodi, S Petanidis, D Anestakis… - Frontiers in …, 2024 - frontiersin.org
A significant factor in the antitumor immune response is the increased metabolic
reprogramming of immunological and malignant cells. Increasing data points to the fact that …

Ferroptosis-driven nanotherapeutics to reverse drug resistance in tumor microenvironment

L Zhu, D Meng, X Wang, X Chen - ACS Applied Bio Materials, 2022 - ACS Publications
Ferroptosis, characterized by iron-dependent lipid reactive oxygen species (ROS)
accumulation, is non-apoptotic programmed cell death highly relevant to tumor …

[HTML][HTML] NADK-mediated de novo NADP (H) synthesis is a metabolic adaptation essential for breast cancer metastasis

D Ilter, S Drapela, T Schild, NP Ward, E Adhikari, V Low… - Redox Biology, 2023 - Elsevier
Metabolic reprogramming and metabolic plasticity allow cancer cells to fine-tune their
metabolism and adapt to the ever-changing environments of the metastatic cascade, for …

Fatty acid synthase: a druggable driver of breast cancer brain metastasis

JA Menendez, R Lupu - Expert opinion on therapeutic targets, 2022 - Taylor & Francis
ABSTRACT Introduction Brain metastasis (BrM) is a key contributor to morbidity and
mortality in breast cancer patients, especially among high-risk epidermal growth factor …

[HTML][HTML] Unveiling Disrupted Lipid Metabolism in Benign Prostate Hyperplasia, Prostate Cancer, and Metastatic Patients: Insights from a Colombian Nested Case …

D Pardo-Rodriguez, M Santamaría-Torres, A Salinas… - Cancers, 2023 - mdpi.com
Simple Summary Prostate cancer represents a substantial global health issue, and its
intricacies continue to pose challenges for complete comprehension. In this study, an …

[HTML][HTML] Glutamine withdrawal leads to the preferential activation of lipid metabolism in metastatic colorectal cancer

AEG Taşkıran, DA Karaoğlu, CC Eylem, Ç Ermiş… - Translational …, 2024 - Elsevier
Introduction Glutamine is a non-essential amino acid that is critical for cell growth. However,
the differential metabolism of l-glutamine in metastatic versus primary colorectal cancer …

Lipid dysregulation in triple negative breast cancer: Insights from mass spectrometry-based approaches

X Huang, A Ali, DEI Yachioui, SE Le Dévédec… - Progress in Lipid …, 2025 - Elsevier
Triple negative breast cancer (TNBC) has the worst prognosis among breast cancers due to
its aggressive nature and the absence of targeted treatments. Development of novel anti …