Abstract The original Human Connectome Project yielded a rich data set on structural and
functional connectivity in a large sample of healthy young adults using improved methods of …

Currently, over five million Americans suffer with Alzheimer's disease (AD). In the absence of
a cure, this number could increase to 13.8 million by 2050. A critical goal of biomedical …

Subclinical cerebrovascular disease is frequently identified in neuroimaging studies and is
thought to play a role in the pathogenesis of cognitive disorders. Identifying the etiologies of …

Quantitative MRI modalities, such as diffusion tensor imaging (DTI) or magnetization transfer
imaging (MTI) are sensitive to the neuronal effects of aging of the cerebral white matter …

Background The oldest-old (subjects aged 90 years and older) population represents the
fastest growing segment of society and shows a high dementia prevalence rate of up to …

The global fractional anisotropy (gFA) is a structural marker of white matter myelination and
integrity. Previous studies already evidenced that aging-related reduced integrity of specific …

Normal aging is associated with changes in volumetric indices of brain atrophy. A
quantitative understanding of age-related brain changes can shed light on successful aging …

Diffusion MRI is extensively used to investigate changes in white matter microstructure.
However, diffusion measures within white matter tissue can be affected by partial volume …

Magnetic resonance imaging (MRI) studies of brain and neurocognitive aging rarely include
oldest-old adults (ages 80+). But predictions of neurocognitive aging theories derived from …

Objective To investigate if the association between MRI-detectable white matter
hyperintensity (WMH) and cognitive status reported in previous studies persists at older …