Design and application of fluorescent probes to detect cellular physical microenvironments

J Ma, R Sun, K **, A Laskin… - Nature …, 2018 - nature.com
The importance of organic aerosol particles in the environment has been long established,
influencing cloud formation and lifetime, absorbing and scattering sunlight, affecting …

Targeted solvatochromic fluorescent probes for imaging lipid order in organelles under oxidative and mechanical stress

DI Danylchuk, PH Jouard… - Journal of the American …, 2021 - ACS Publications
Biomembranes constitute a basis for all compartments of live cells, and therefore, the
monitoring of their lipid organization is essential for understanding cell status and activity …

Molecular rotors: fluorescent sensors for microviscosity and conformation of biomolecules

M Paez‐Perez, MK Kuimova - Angewandte Chemie, 2024 - Wiley Online Library
The viscosity and crowding of biological environment are considered vital for the correct
cellular function, and alterations in these parameters are known to underly a number of …

Designing a green-emitting viscosity-sensitive 4, 4-difluoro-4-bora-3a, 4a-diaza-s-indacene (BODIPY) probe for plasma membrane viscosity imaging

A Polita, M Stancikaitė, R Žvirblis, K Maleckaitė… - RSC …, 2023 - pubs.rsc.org
Viscosity is a key characteristic of lipid membranes–it governs the passive diffusion of
solutes and affects the lipid raft formation and membrane fluidity. Precise determination of …

Exploring viscosity, polarity and temperature sensitivity of BODIPY-based molecular rotors

A Vyšniauskas, I López-Duarte, N Duchemin… - Physical Chemistry …, 2017 - pubs.rsc.org
Microviscosity is a key parameter controlling the rate of diffusion and reactions on the
microscale. One of the most convenient tools for measuring microviscosity is by fluorescent …

Monitoring membrane viscosity in differentiating stem cells using BODIPY-based molecular rotors and FLIM

AS Kashirina, I López-Duarte, M Kubánková… - Scientific reports, 2020 - nature.com
Membrane fluidity plays an important role in many cell functions such as cell adhesion, and
migration. In stem cell lines membrane fluidity may play a role in differentiation. Here we …

Unravelling the effect of temperature on viscosity-sensitive fluorescent molecular rotors

A Vyšniauskas, M Qurashi, N Gallop, M Balaz… - Chemical …, 2015 - pubs.rsc.org
Viscosity and temperature variations in the microscopic world are of paramount importance
for diffusion and reactions. Consequently, a plethora of fluorescent probes have evolved …

Directly imaging emergence of phase separation in peroxidized lipid membranes

M Paez-Perez, A Vyšniauskas, I López-Duarte… - Communications …, 2023 - nature.com
Lipid peroxidation is a process which is key in cell signaling and disease, it is exploited in
cancer therapy in the form of photodynamic therapy. The appearance of hydrophilic moieties …

Imaging tumor microscopic viscosity in vivo using molecular rotors

LE Shimolina, MA Izquierdo, I López-Duarte, JA Bull… - Scientific reports, 2017 - nature.com
The microscopic viscosity plays an essential role in cellular biophysics by controlling the
rates of diffusion and bimolecular reactions within the cell interior. While several approaches …