The field of flow chemistry has garnered considerable attention over the past 2 decades.
This Perspective highlights many recent advances in the field of flow chemistry and …

Introduction: For the manufacture of small molecule drugs, many pharmaceutical innovator
companies have recently invested in continuous processing, which can offer significant …

There has been an increasing interest in the use of automated self-optimising continuous
flow platforms for the development and manufacture in synthesis in recent years. Such …

This manuscript provides the results of an in-depth survey assessment of the capabilities,
experience, and perspectives on continuous processing in the pharmaceutical sector, with …

A nanocatalyst for micellar Buchwald–Hartwig aminations is developed, thoroughly
characterized, and applied on a variety of substrates. The catalyst is stable under ambient …

Herein, we report on the development of a waste minimization/valorization methodology
applied to the representative benchmark Sonogashira cross-coupling reaction performed in …

The abundance, structural diversity, and versatility of ketones give prominence to this
carbonyl functional group in synthetic chemistry. The assembly of ketones via the …

Continuous flow processing continues to garner interest in the pharmaceutical industry for
the production of small-molecule drug substances given the advantages associated with …

We developed a scalable Suzuki process for the synthesis of lanabecestat (+)-camsylate, an
active pharmaceutical ingredient that was recently investigated in a Phase III clinical …

We report the development of an organolithium addition to a chiral ketimine at pilot-plant
scale using flow chemistry. Given the mixing sensitivity of this process, established …