Central gain control in tinnitus and hyperacusis
Sensorineural hearing loss induced by noise or ototoxic drug exposure reduces the neural
activity transmitted from the cochlea to the central auditory system. Despite a reduced …
activity transmitted from the cochlea to the central auditory system. Despite a reduced …
KCNQ-encoded potassium channels as therapeutic targets
Kv7 channels are voltage-gated potassium channels encoded by KCNQ genes that have a
considerable physiological impact in many cell types. This reliance upon Kv7 channels for …
considerable physiological impact in many cell types. This reliance upon Kv7 channels for …
Methodological aspects of clinical trials in tinnitus: a proposal for an international standard
M Landgrebe, A Azevedo, D Baguley, C Bauer… - Journal of …, 2012 - Elsevier
Chronic tinnitus is a common condition with a high burden of disease. While many different
treatments are used in clinical practice, the evidence for the efficacy of these treatments is …
treatments are used in clinical practice, the evidence for the efficacy of these treatments is …
[HTML][HTML] Review of salicylate-induced hearing loss, neurotoxicity, tinnitus and neuropathophysiology
Salicylate's ototoxic properties have been well established, inducing tinnitus and a sensory
hearing loss when administered in high doses. Peripherally, acute dosing of salicylate …
hearing loss when administered in high doses. Peripherally, acute dosing of salicylate …
Salicylate-induced cochlear impairments, cortical hyperactivity and re-tuning, and tinnitus
High doses of sodium salicylate (SS) have long been known to induce temporary hearing
loss and tinnitus, effects attributed to cochlear dysfunction. However, our recent publications …
loss and tinnitus, effects attributed to cochlear dysfunction. However, our recent publications …
Activation of KCNQ4 as a therapeutic strategy to treat hearing loss
Potassium voltage-gated channel subfamily q member 4 (KCNQ4) is a voltage-gated
potassium channel that plays essential roles in maintaining ion homeostasis and regulating …
potassium channel that plays essential roles in maintaining ion homeostasis and regulating …
Effects of mobile phase composition and temperature on the supercritical fluid chromatography enantioseparation of chiral fluoro-oxoindole-type compounds with …
C West, A Bouet, S Routier, E Lesellier - Journal of Chromatography a, 2012 - Elsevier
The indole ring is present in many pharmaceutically active compounds, as in MaxiPost™(or
BMS-204352), an active pharmaceutical ingredient for post-stroke neuroprotection. Two …
BMS-204352), an active pharmaceutical ingredient for post-stroke neuroprotection. Two …
Chemical modulation of Kv7 potassium channels
The rising interest in Kv7 modulators originates from their ability to evoke fundamental
electrophysiological perturbations in a tissue-specific manner. A large number of therapeutic …
electrophysiological perturbations in a tissue-specific manner. A large number of therapeutic …
Animal models of subjective tinnitus
W von der Behrens - Neural plasticity, 2014 - Wiley Online Library
Tinnitus is one of the major audiological diseases, affecting a significant portion of the
ageing society. Despite its huge personal and presumed economic impact there are only …
ageing society. Despite its huge personal and presumed economic impact there are only …
[HTML][HTML] Pharmacologic treatments in preclinical tinnitus models with special focus on Ginkgo biloba leaf extract EGb 761®
SW Barth, MD Lehner, GPH Dietz, H Schulze - Molecular and Cellular …, 2021 - Elsevier
Tinnitus is defined as the perception of sound in the absence of external acoustic stimuli.
Frequent comorbidities or associated factors are depression, anxiety, concentration …
Frequent comorbidities or associated factors are depression, anxiety, concentration …