Despite declines in heart failure morbidity and mortality with current therapies,
rehospitalization rates remain distressingly high, substantially affecting individuals, society …

The giant sarcomere protein titin is a major determinant of cardiomyocyte stiffness and
contributor to cardiac strain sensing. Titin-based forces are highly regulated in health and …

The sarcomeric interaction of α-myosin heavy chain (α-MHC) with Titin is vital for cardiac
structure and contraction. However, the mechanism regulating this interaction in normal and …

Human mutations that truncate the massive sarcomere protein titin [TTN-truncating variants
(TTNtvs)] are the most common genetic cause for dilated cardiomyopathy (DCM), a major …

The heart hypertrophies in response to developmental signals as well as increased
workload. Although adult-onset hypertrophy can ultimately lead to disease, cardiac …

Left ventricular (LV) hypertrophy (LVH) is a growth in left myocardial mass mainly caused by
increased cardiomyocyte size. LVH can be a physiological adaptation to physical exercise …

The giant protein titin forms a unique filament network in cardiomyocytes, which engages in
both mechanical and signaling functions of the heart. TTN, which encodes titin, is also a …

The thin and thick filaments of muscle sarcomeres are interconnected by the giant protein
titin, which is a scaffolding filament, signaling platform, and provider of passive tension and …

LVEF indicates left ventricular ejection fraction; CMR, cardiac magnetic resonance; LGE, late
gadolinium enhancement; TDI, tissue Doppler imaging; LVOTO, left ventricular outflow tract …

Functional changes in spatial genome organization during human development are poorly
understood. Here we report a comprehensive profile of nuclear dynamics during human …