Adeno-associated viral (AAV) vectors are a rapidly emerging gene therapy platform for the
treatment of neurological diseases. In preclinical studies, transgenes encoding therapeutic …

Gene therapy is rapidly emerging as a powerful therapeutic strategy for a wide range of
neurodegenerative disorders, including Alzheimer's disease (AD), Parkinson's disease (PD) …

Recombinant adeno-associated viral vectors (AAVs) are an effective system for gene
transfer. AAV serotype 2 (AAV2) is commonly used to deliver transgenes to retinal ganglion …

Here we investigated the transduction characteristics of adeno-associated viral vector (AAV)
serotypes 1, 2, 5, 8 and 9 in the marmoset cerebral cortex. Using three constructs that each …

The gate control theory of pain proposes that inhibitory neurons of the spinal dorsal horn
exert critical control over the relay of nociceptive signals to higher brain areas. Here we …

More than one hundred naturally occurring variants of adeno-associated virus (AAV) have
been identified, and this library has been further expanded by an array of techniques for …

Adeno-associated viral vectors are widely used as vehicles for gene transfer to the nervous
system. The promoter and viral vector serotype are two key factors that determine the …

Different glial cell types are found throughout the central (CNS) and peripheral nervous
system (PNS), where they have important functions. These cell types are also involved in …

Chronic spinal cord injury (SCI) is a formidable hurdle that prevents a large number of
injured axons from crossing the lesion, particularly the corticospinal tract (CST). This study …

Mutations in the GJB1 gene, encoding the gap junction (GJ) protein connexin32 (Cx32),
cause X-linked Charcot-Marie-Tooth disease (CMT1X), an inherited demyelinating …