Gold nanoparticles: promising nanomaterials for the diagnosis of cancer and HIV/AIDS

A Kumar, B Mazinder Boruah… - Journal of …, 2011 - Wiley Online Library
Gold nanoparticles (AuNPs) are currently playing a significant role for human welfare in the
field of clinical diagnosis as well as several biomedical applications. More and more …

Grading the commercial optical biosensor literature—Class of 2008:'The Mighty Binders'

RL Rich, DG Myszka - Journal of Molecular Recognition: An …, 2010 - Wiley Online Library
Optical biosensor technology continues to be the method of choice for label‐free, real‐time
interaction analysis. But when it comes to improving the quality of the biosensor literature …

Applying mass spectrometry to study non‐covalent biomolecule complexes

F Chen, B Gülbakan, S Weidmann… - Mass spectrometry …, 2016 - Wiley Online Library
Non‐covalent interactions are essential for the structural organization of biomacromolecules
and play an important role in molecular recognition processes, such as the interactions …

TREM-1 multimerization is essential for its activation on monocytes and neutrophils

K Carrasco, A Boufenzer, L Jolly, H Le Cordier… - Cellular & Molecular …, 2019 - nature.com
The triggering receptor expressed on myeloid cells-1 (TREM-1) is a receptor expressed on
innate immune cells. By promoting the amplification of inflammatory signals that are initially …

Analytical methods for kinetic studies of biological interactions: A review

X Zheng, C Bi, Z Li, M Podariu, DS Hage - Journal of pharmaceutical and …, 2015 - Elsevier
The rates at which biological interactions occur can provide important information
concerning the mechanism and behavior of these processes in living systems. This review …

Conjugating immunoassays to mass spectrometry: Solutions to contemporary challenges in clinical diagnostics

KG Stevens, TL Pukala - TrAC Trends in Analytical Chemistry, 2020 - Elsevier
Developments in immunoassays and mass spectrometry have independently influenced
diagnostic technology. However, both techniques possess unique strengths and limitations …

Extending mass spectrometry contribution to therapeutic monoclonal antibody lead optimization: characterization of immune complexes using noncovalent ESI-MS

C Atmanene, E Wagner-Rousset, M Malissard… - Analytical …, 2009 - ACS Publications
Monoclonal antibodies (mAbs) have taken on an increasing importance for the treatment of
various diseases including cancers, immunological disorders, and other pathologies. These …

The reaction of hydrogen peroxide with hemoglobin induces extensive α-globin crosslinking and impairs the interaction of hemoglobin with endogenous scavenger …

F Vallelian, T Pimenova, CP Pereira, B Abraham… - Free Radical Biology …, 2008 - Elsevier
Cell-free hemoglobin (Hb) enhances the oxidation-related toxicity associated with
inflammation, ischemia, and hemolytic disorders. Hb is highly vulnerable to oxidative …

Au-nanoparticles as an electrochemical sensing platform for aptamer–thrombin interaction

E Suprun, V Shumyantseva, T Bulko… - Biosensors and …, 2008 - Elsevier
A novel electrochemical method for the detection of bioaffinity interactions based on a gold-
nanoparticles sensing platform and on the usage of strip** voltammetry technique was …

Reactivity and applications of new amine reactive cross-linkers for mass spectrometric detection of protein− protein complexes

C Bich, S Maedler, K Chiesa, F DeGiacomo… - Analytical …, 2010 - ACS Publications
Chemical cross-linking of proteins permits the stabilization of noncovalent complexes
through introduction of covalent bonds. A crucial challenge is to find the fastest and most …