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The comparative immunological characteristics of SARS-CoV, MERS-CoV, and SARS-CoV-2 coronavirus infections
Y Zhang, B Li, B Ning - Frontiers in Immunology, 2020 - frontiersin.org
Immune dysfunction and aberrant cytokine storms often lead to rapid exacerbation of the
disease during late infection stages in SARS-CoV and MERS-CoV patients. However, the …
disease during late infection stages in SARS-CoV and MERS-CoV patients. However, the …
Neutralizing and protective human monoclonal antibodies recognizing the N-terminal domain of the SARS-CoV-2 spike protein
N Suryadevara, S Shrihari, P Gilchuk, LA VanBlargan… - Cell, 2021 - cell.com
Most human monoclonal antibodies (mAbs) neutralizing SARS-CoV-2 recognize the spike
(S) protein receptor-binding domain and block virus interactions with the cellular receptor …
(S) protein receptor-binding domain and block virus interactions with the cellular receptor …
[HTML][HTML] T-cell epitope-based vaccines: A promising strategy for prevention of infectious diseases
X Song, Y Li, H Wu, HJ Qiu, Y Sun - Vaccines, 2024 - mdpi.com
With the development of novel vaccine strategies, T-cell epitope-based vaccines have
become promising prophylactic and therapeutic tools against infectious diseases that cannot …
become promising prophylactic and therapeutic tools against infectious diseases that cannot …
Peptide microarray‐based analysis of antibody responses to SARS‐CoV‐2 identifies unique epitopes with potential for diagnostic test development
P Holenya, PJ Lange, U Reimer… - European Journal of …, 2021 - Wiley Online Library
Humoral immunity to the Severe Adult Respiratory Syndrome (SARS) Coronavirus (CoV)‐2
is not fully understood yet but is a crucial factor of immune protection. The possibility of …
is not fully understood yet but is a crucial factor of immune protection. The possibility of …
Immune Epitopes of SARS-CoV-2 Spike Protein and Considerations for Universal Vaccine Development
N Magazine, T Zhang, AD Bungwon, MC McGee… - …, 2024 - journals.aai.org
Despite the success of global vaccination programs in slowing the spread of COVID-19,
these efforts have been hindered by the emergence of new SARS-CoV-2 strains capable of …
these efforts have been hindered by the emergence of new SARS-CoV-2 strains capable of …
Development of T cell antigen-based human coronavirus vaccines against nAb-esca** SARS-CoV-2 variants
H Zhou, P Leng, Y Wang, K Yang, C Li, DM Ojcius… - Science Bulletin, 2024 - Elsevier
Currently approved vaccines have been successful in preventing the severity of COVID-19
and hospitalization. These vaccines primarily induce humoral immune responses; however …
and hospitalization. These vaccines primarily induce humoral immune responses; however …
[PDF][PDF] Prediction of SARS-CoV-2 epitopes across 9360 HLA class I alleles
Elucidating antiviral CD8 T lymphocyte responses to SARS-CoV-2 may shed light on the
heterogeneity of clinical outcomes and inform vaccine or therapeutic approaches. To …
heterogeneity of clinical outcomes and inform vaccine or therapeutic approaches. To …
The answer lies in the energy: how simple atomistic molecular dynamics simulations may hold the key to epitope prediction on the fully glycosylated SARS-CoV-2 …
SARS-CoV-2 is a health threat with dire socioeconomical consequences. As the crucial
mediator of infection, the viral glycosylated spike protein (S) has attracted the most attention …
mediator of infection, the viral glycosylated spike protein (S) has attracted the most attention …
The understanding of any disease calls for studying specific biological structures called
epitopes. One important tool recently drawing attention and improving efficiency in both …
epitopes. One important tool recently drawing attention and improving efficiency in both …
SARS-CoV-2 spike protein mutations and escape from antibodies: a computational model of epitope loss in variants of concern
The SARS-CoV-2 spike (S) protein is exposed on the viral surface and is the first point of
contact between the virus and the host. For these reasons it represents the prime target for …
contact between the virus and the host. For these reasons it represents the prime target for …