Secondary immunodeficiencies: an overview
KS Tuano, N Seth, J Chinen - Annals of Allergy, Asthma & Immunology, 2021 - Elsevier
Objective To review the different causes of secondary immunodeficiencies and provide
clinicians with an updated overview of potential factors that contribute to immunodeficiency …
clinicians with an updated overview of potential factors that contribute to immunodeficiency …
Deep sequencing of B cell receptor repertoires from COVID-19 patients reveals strong convergent immune signatures
Deep sequencing of B cell receptor (BCR) heavy chains from a cohort of 31 COVID-19
patients from the UK reveals a stereotypical naive immune response to SARS-CoV-2 which …
patients from the UK reveals a stereotypical naive immune response to SARS-CoV-2 which …
[HTML][HTML] Understanding heterogeneity of human bone marrow plasma cell maturation and survival pathways by single-cell analyses
Human bone marrow (BM) plasma cells are heterogeneous, ranging from newly arrived
antibody-secreting cells (ASCs) to long-lived plasma cells (LLPCs). We provide single-cell …
antibody-secreting cells (ASCs) to long-lived plasma cells (LLPCs). We provide single-cell …
Polyfunctional antibodies: a path towards precision vaccines for vulnerable populations
Vaccine efficacy determined within the controlled environment of a clinical trial is usually
substantially greater than real-world vaccine effectiveness. Typically, this results from …
substantially greater than real-world vaccine effectiveness. Typically, this results from …
Genetic variation in the immunoglobulin heavy chain locus shapes the human antibody repertoire
Variation in the antibody response has been linked to differential outcomes in disease, and
suboptimal vaccine and therapeutic responsiveness, the determinants of which have not …
suboptimal vaccine and therapeutic responsiveness, the determinants of which have not …
Cross-reactive antibodies against human coronaviruses and the animal coronavirome suggest diagnostics for future zoonotic spillovers
The spillover of animal coronaviruses (aCoVs) to humans has caused SARS, MERS, and
COVID-19. Although antibody responses displaying cross-reactivity between SARS-CoV-2 …
COVID-19. Although antibody responses displaying cross-reactivity between SARS-CoV-2 …
Maturation of the human immunoglobulin heavy chain repertoire with age
B cells play a central role in adaptive immune processes, mainly through the production of
antibodies. The maturation of the B cell system with age is poorly studied. We extensively …
antibodies. The maturation of the B cell system with age is poorly studied. We extensively …
BNT162b2 booster after heterologous prime-boost vaccination induces potent neutralizing antibodies and T cell reactivity against SARS-CoV-2 Omicron BA. 1 in …
A Seidel, M Zanoni, R Groß, D Krnavek… - Frontiers in …, 2022 - frontiersin.org
In light of the decreasing immune protection against symptomatic SARS-CoV-2 infection
after initial vaccinations and the now dominant immune-evasive Omicron variants,'booster' …
after initial vaccinations and the now dominant immune-evasive Omicron variants,'booster' …
B-cell reconstitution after autologous hematopoietic stem cell transplantation in multiple sclerosis
Background and Objectives Autologous hematopoietic stem cell transplantation (aHSCT) is
increasingly used to treat aggressive forms of multiple sclerosis (MS). This procedure is …
increasingly used to treat aggressive forms of multiple sclerosis (MS). This procedure is …
Different B cell subpopulations show distinct patterns in their IgH repertoire metrics
Several human B cell subpopulations are recognised in the peripheral blood, which play
distinct roles in the humoral immune response. These cells undergo developmental and …
distinct roles in the humoral immune response. These cells undergo developmental and …