Classic psychedelic drugs such as psilocybin and lysergic acid diethylamide (LSD) have
recaptured the imagination of both science and popular culture, and may have efficacy in …

Previous attempts to identify a unified theory of brain serotonin function have largely failed to
achieve consensus. In this present synthesis, we integrate previous perspectives with new …

The entropic brain hypothesis proposes that within upper and lower limits, after which
consciousness may be lost, the entropy of spontaneous brain activity indexes the …

Aims: The experience of a compromised sense of “self”, termed ego-dissolution, is a key
feature of the psychedelic experience. This study aimed to validate the Ego-Dissolution …

There is growing interest in the therapeutic utility of psychedelic substances, like psilocybin,
for disorders characterized by distortions of the self-experience, like depression …

Lysergic acid diethylamide (LSD) is a non-selective serotonin-receptor agonist that was first
synthesized in 1938 and identified as (potently) psychoactive in 1943. Psychedelics have …

Entropy is a dimensionless quantity that is used for measuring uncertainty about the state of
a system but it can also imply physical qualities, where high entropy is synonymous with …

Brains at rest generate dynamical activity that is highly structured in space and time. We
suggest that spontaneous activity, as in rest or dreaming, underlies top-down dynamics of …

Is the self already relational in its very bodily foundations? The question of whether our
mental life is initially and primarily shaped by embodied dimensions of the individual or by …

This paper introduces a new construct, the 'pivotal mental state', which is defined as a hyper-
plastic state aiding rapid and deep learning that can mediate psychological transformation …