Since Cajal's first drawings of Golgi stained neurons, generations of researchers have been
fascinated by the small protrusions, termed spines, studding many neuronal dendrites. Most …

Dendritic spines are small, thin, specialized protrusions from neuronal dendrites, primarily
localized in the excitatory synapses. Sophisticated imaging techniques revealed that …

Dendritic spines are small protrusions from the dendrite membrane, where contact with
neighboring axons is formed in order to receive synaptic input. Changes in size, shape, and …

Dynamic change of mitochondrial morphology and distribution along neuronal branches are
essential for neural circuitry formation and synaptic efficacy. However, the underlying …

Over the past decade, compelling genetic evidence has highlighted the crucial role of
microglial dysregulation in the development of Alzheimer's disease (AD). As resident …

Activity-induced modification of neuronal connections is essential for the development of the
nervous system and may also underlie learning and memory functions of mature brain …

During development, neural networks are established in a highly organized manner, which
persists throughout life. Neurotrophins play crucial roles in the develo** nervous system …

Electrophysiological connectivity patterns in cortex often have a few strong connections,
which are sometimes bidirectional, among a lot of weak connections. To explain these …

Synapse regulation exploits the capacity of actin to function as a stable structural component
or as a dynamic filament. Beyond its well-appreciated role in eliciting visible morphological …

Rewiring neural circuits by the formation and elimination of synapses is thought to be a key
cellular mechanism of learning and memory in the mammalian brain. Dendritic spines are …