Omics techniques generate large, multidimensional data that are amenable to analysis by
new informatics approaches alongside conventional statistical methods. Systems theories …

During the past decade, genome‐wide association studies (GWAS) have transformed our
understanding of many heritable traits. Three recent large‐scale GWAS meta‐analyses now …

The development and progression of cardiovascular disease (CVD) can mainly be attributed
to the narrowing of blood vessels caused by atherosclerosis and thrombosis, which induces …

Cardiovascular diseases are the leading cause of death around the world. Despite the
larger number of genes and loci identified, the precise mechanisms by which these genes …

Cardiovascular diseases (CVD) annually take almost 18 million lives worldwide. Most lethal
events occur months or years after the initial presentation. Indeed, many patients experience …

Most complex diseases involve genetic and environmental risk factors, engage multiple cells
and tissues, and follow a polygenic or omnigenic model depicting numerous genes …

Introduction The top priority in drug development is to identify novel and effective drug
targets. In vitro assays are frequently used for this purpose; however, traditional …

Network medicine can advance current medical practice by arising as response to the
limitations of a reductionist approach focusing on cardiovascular (CV) diseases as a direct …

Genome-wide association studies have led to a significant progress in identification of
genomic loci affecting coronary artery disease (CAD) risk. However, revealing the causal …

The achievement of genome-wide association studies (GWAS) has rapidly progressed our
understanding of the etiology of coronary artery disease (CAD). It unlocks new strategies to …