The fundamental roles that peptides and proteins play in today's biology makes it almost
indisputable that peptides were key players in the origin of life. Insofar as it is appropriate to …

Protein–protein interactions (PPIs) are involved at all levels of cellular organization, thus
making the development of PPI inhibitors extremely valuable. The identification of selective …

The majority of therapeutics target membrane proteins, accessible on the surface of cells, to
alter cellular signaling. Cells use membrane proteins to transduce signals into cells …

Since Hedin's characterization of trypsin and antitrypsin in 1906,(1) arguably the first
account of a regulatory protein–protein interaction (PPI), contemporary understanding of …

This paper discusses the role of peptides in cancer therapy with special emphasis on
peptide drugs which are already approved and those in clinical trials. The potential of …

Peptidomimetics represent an important field in chemistry, pharmacology and material
science as they circumvent the limitations of traditional peptides used in therapy. Self …

Antimicrobial peptides (AMPs) provide protection against a variety of pathogenic bacteria
and are, therefore, an important part of the innate immune system. Over the past decade …

Foldamers are sequence-specific oligomers akin to peptides, proteins and oligonucleotides
that fold into well-defined three-dimensional structures. They offer the chemical biologist a …

For more than a decade now, a search for answers to the following two questions has taken
us on a new and exciting journey into the world of β-and γ-peptides: What happens if the …

There is a general need for the engineering of protein-like molecules that organize into
geometrically specific superstructures on molecular surfaces, directing further …