Cilium structure, assembly, and disassembly regulated by the cytoskeleton
The cilium, once considered a vestigial structure, is a conserved, microtubule-based
organelle critical for transducing extracellular chemical and mechanical signals that control …
organelle critical for transducing extracellular chemical and mechanical signals that control …
Multiciliated cells
Cilia are microtubule-based projections that serve a wide variety of essential functions in
animal cells. Defects in cilia structure or function have recently been found to underlie …
animal cells. Defects in cilia structure or function have recently been found to underlie …
[HTML][HTML] TGF-β signaling is associated with endocytosis at the pocket region of the primary cilium
CA Clement, KD Ajbro, K Koefoed, ML Vestergaard… - Cell reports, 2013 - cell.com
Transforming growth factor β (TGF-β) signaling is regulated by clathrin-dependent
endocytosis (CDE) for the control of cellular processes during development and in tissue …
endocytosis (CDE) for the control of cellular processes during development and in tissue …
[HTML][HTML] Ciliogenesis membrane dynamics and organization
Ciliogenesis is a complex multistep process used to describe assembly of cilia and flagella.
These organelles play essential roles in motility and signaling on the surface of cells. Cilia …
These organelles play essential roles in motility and signaling on the surface of cells. Cilia …
Stages of ciliogenesis and regulation of ciliary length
Cilia and flagella are highly conserved eukaryotic microtubule-based organelles that
protrude from the surface of most mammalian cells. These structures require large protein …
protrude from the surface of most mammalian cells. These structures require large protein …
The molecular structure of mammalian primary cilia revealed by cryo-electron tomography
Primary cilia are microtubule-based organelles that are important for signaling and sensing
in eukaryotic cells. Unlike the thoroughly studied motile cilia, the three-dimensional …
in eukaryotic cells. Unlike the thoroughly studied motile cilia, the three-dimensional …
A Proteome-wide screen for mammalian SxIP motif-containing microtubule plus-end tracking proteins
Microtubule plus-end tracking proteins (+ TIPs) are structurally and functionally diverse
factors that accumulate at the growing microtubule plus-ends, connect them to various …
factors that accumulate at the growing microtubule plus-ends, connect them to various …
Functional aspects of primary cilia in signaling, cell cycle and tumorigenesis
SG Basten, RH Giles - Cilia, 2013 - Springer
Dysfunctional cilia underlie a broad range of cellular and tissue phenotypes and can
eventually result in the development of ciliopathies: pathologically diverse diseases that …
eventually result in the development of ciliopathies: pathologically diverse diseases that …
Cilia, Wnt signaling, and the cytoskeleton
HL May-Simera, MW Kelley - Cilia, 2012 - Springer
Primary cilia have recently been highlighted as key regulators in development and disease.
This review focuses on current work demonstrating the broad role of cilia-related proteins in …
This review focuses on current work demonstrating the broad role of cilia-related proteins in …
Primary cilia and coordination of receptor tyrosine kinase (RTK) signalling
ST Christensen, CA Clement, P Satir… - The Journal of …, 2012 - Wiley Online Library
Primary cilia are microtubule‐based sensory organelles that coordinate signalling pathways
in cell‐cycle control, migration, differentiation and other cellular processes critical during …
in cell‐cycle control, migration, differentiation and other cellular processes critical during …