Allostery is the process by which biological macromolecules (mostly proteins) transmit the
effect of binding at one site to another, often distal, functional site, allowing for regulation of …

All soluble proteins populate conformational ensembles that together constitute the native
state. Their fluctuations in water are intrinsic thermodynamic phenomena, and the …

Allostery is largely associated with conformational and functional transitions in individual
proteins. This concept can be extended to consider the impact of conformational …

This tutorial review summarises different aspects of cooperativity in supramolecular
complexes. We propose a systematic categorisation of cooperativity into cooperative …

Proteins are inherently flexible at ambient temperature. At equilibrium, they are
characterized by a set of conformations that undergo continuous exchange within a …

Mammalian ATP-gated nonselective cation channels (P2XRs) can be composed of seven
possible subunits, denoted P2X1 to P2X7. Each subunit contains a large ectodomain, two …

Allosteric drug development holds promise for delivering medicines that are more selective
and less toxic than those that target orthosteric sites. To date, the discovery of allosteric …

Asymmetric catalysis plays a key role in modern synthetic organic chemistry, with synthetic
catalysts and enzymes being the two available options. During the latter part of the last …

First worldwide family litigation filed litigation Critical https://patents. darts-ip. com/? family=
52463182&utm_source= google_patent&utm_medium= platform_link&utm_campaign …

The discovery of fullerenes has opened up new studies in shaped carbon materials. In
particular the discovery that carbon atoms in fullerenes showed curved sp2 bonding also led …