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Role of circular RNAs in brain development and CNS diseases
In mammals, many classes of noncoding RNAs (ncRNAs) are expressed at a much higher
level in the brain than in other organs. Recent studies have identified a new class of ncRNAs …
level in the brain than in other organs. Recent studies have identified a new class of ncRNAs …
A systematic review of the research progress of non-coding RNA in neuroinflammation and immune regulation in cerebral infarction/ischemia-reperfusion injury
Cerebral infarction/ischemia-reperfusion injury is currently the disease with the highest
mortality and disability rate of cardiovascular disease. Current studies have shown that …
mortality and disability rate of cardiovascular disease. Current studies have shown that …
Extracellular vesicle–mediated delivery of circular RNA SCMH1 promotes functional recovery in rodent and nonhuman primate ischemic stroke models
Background: Stroke is a leading cause of adult disability that can severely compromise the
quality of life of patients, yet no effective medication currently exists to accelerate …
quality of life of patients, yet no effective medication currently exists to accelerate …
FTO-dependent m6A modification of Plpp3 in circSCMH1-regulated vascular repair and functional recovery following stroke
B Li, W **, Y Bai, X Liu, Y Zhang, L Li, L Bian… - Nature …, 2023 - nature.com
Vascular repair is considered a key restorative measure to improve long-term outcomes after
ischemic stroke. N 6-methyladenosine (m6A), the most prevalent internal modification in …
ischemic stroke. N 6-methyladenosine (m6A), the most prevalent internal modification in …
Integrating spatial and single-cell transcriptomics to characterize the molecular and cellular architecture of the ischemic mouse brain
Neuroinflammation is acknowledged as a pivotal pathological event after cerebral ischemia.
However, there is limited knowledge of the molecular and spatial characteristics of …
However, there is limited knowledge of the molecular and spatial characteristics of …
CircOGDH is a penumbra biomarker and therapeutic target in acute ischemic stroke
Background: Acute ischemic stroke (AIS) is a leading cause of disability and mortality
worldwide. Prediction of penumbra existence after AIS is crucial for making decision on …
worldwide. Prediction of penumbra existence after AIS is crucial for making decision on …
Mechanisms of circular RNA degradation
L Ren, Q Jiang, L Mo, L Tan, Q Dong, L Meng… - Communications …, 2022 - nature.com
Abstract Circular RNAs (CircRNAs) are a class of noncoding RNAs formed by backsplicing
during cotranscriptional and posttranscriptional processes, and they widely exist in various …
during cotranscriptional and posttranscriptional processes, and they widely exist in various …
Circular RNAs: expression, localization, and therapeutic potentials
Circular RNAs (circRNAs) are RNAs with a unique circular structure that is generated from
back-splicing processes. These circular molecules were discovered more than 40 years ago …
back-splicing processes. These circular molecules were discovered more than 40 years ago …
[HTML][HTML] Fasting-mimicking diet cycles reduce neuroinflammation to attenuate cognitive decline in Alzheimer's models
The effects of fasting-mimicking diet (FMD) cycles in reducing many aging and disease risk
factors indicate it could affect Alzheimer's disease (AD). Here, we show that FMD cycles …
factors indicate it could affect Alzheimer's disease (AD). Here, we show that FMD cycles …
RETRACTED: Overexpression of circRNA circUCK2 Attenuates Cell Apoptosis in Cerebral Ischemia-Reperfusion Injury via miR-125b-5p/GDF11 Signaling
W Chen, H Wang, J Feng, L Chen - Molecular therapy Nucleic acids, 2020 - cell.com
Circular RNAs (circRNAs) are expressed at high levels in the brain and are involved in
various central nervous system diseases. However, the potential role of circRNAs in …
various central nervous system diseases. However, the potential role of circRNAs in …