Enzyme cascades are a powerful technology to develop environmentally friendly and cost-
effective synthetic processes to manufacture drugs, as they couple different …

As an alternative to the traditional chemical synthesis or in vivo production of L-pipecolic
acid, we have developed two ex vivo strategies using purified and immobilised enzymes for …

The reductive amination (RA) reaction plays a pivotal role in the synthesis of new C–N
bonds, due to the availability of many different and low‐cost reagents and their operational …

Despite the significant role of pyruvic acid in biotransformations, the utilization of pyruvates
in the field of catalytic asymmetric synthesis has been unexpectedly limited. This statement …

A process for the de novo synthesis of imino‐C‐glycosides is described. The methodology is
based on the reaction of 1‐C‐stannylated iminosugars with various electrophiles under the …

A comprehensive study of the preparation and reactivity of N‐tert‐butanesulfinyl
glycosylamines with simple Grignard and organo lithium reagents in batch vs. continuous …

Over the past two decades, organocatalytic aldol reaction emerged as a powerful method for
the enantioselective carbon–carbon bond formation, often offering more efficient …

A study of the chemical composition of polar compounds from seeds of Trigonella caerulea
(L.) Ser.(Fabaceae) revealed the presence of monosaccharides (2 and 3); oligosaccharides …

The direct asymmetric aldol reaction of α‐ketoesters catalyzed by chiral tertiary amines is
reported. The described methodology is characterized by mild reaction conditions and …

1.1 Lysosomal Storage Disorders 3 1.2 Therapeutic approaches to Lysosomal Storage
Disorders 6 1.2. 1 Enzyme replacement therapy 6 1.2. 2 Substrate reduction therapy 7 1.2. 3 …