Cancer progression with uncontrolled tumor growth, local invasion, and metastasis depends
largely on the proteolytic activity of numerous matrix metalloproteinases (MMPs), which …

The extracellular matrix (ECM) constitutes the scaffold of tissues and organs. It is a complex
network of extracellular proteins, proteoglycans and glycoproteins, which form …

Traditional biochemical methods for enzyme detection are mainly based on antibody-based
immunoassays, which lack the ability to monitor the spatiotemporal distribution and, in …

Osteoarthritis (OA) is a chronic musculoskeletal disorder characterized by an imbalance
between (synthesis) and catabolism (degradation) in altered homeostasis of articular …

Fibrosis in adipose tissue is a major driver of obesity-related metabolic dysregulation. It is
characterized by an overaccumulation of extracellular matrix (ECM) during unhealthy …

Membrane-type matrix metalloproteinases (MT-MMPs) form a subgroup of the matrix
metalloproteinase (MMP) family, and there are 6 MT-MMPs in humans. MT-MMPs are further …

Matrix metalloproteinases (MMPs), also called matrixins, function in the extracellular
environment of cells and degrade both matrix and non-matrix proteins. They play central …

Functions of individual matrix metalloproteinases (MMPs) differentially expressed by tumor
cells and stromal cells, are finely regulated by their spatial as well as temporal interactions …

Matrix metalloproteinases (MMPs) are now acknowledged as key players in the regulation of
both cell–cell and cell–extracellular matrix interactions. They are involved in modifying …

It is becoming increasingly clear that signals generated in tumor microenvironments are
crucial to tumor cell behavior, such as survival, progression and metastasis. The …