The thymus plays distinct roles in the pathogenesis of the different Myasthenia gravis (MG)
subtypes. Inflammatory, neoplastic and age-related alterations of the thymus are of pivotal …

Autoimmune diseases represent a heterogeneous group of conditions whose incidence is
increasing worldwide. This has stimulated studies on their etiopathogenesis, derived from a …

The incidence of autoimmune diseases is increasing worldwide, thus stimulating studies on
their etiopathogenesis, derived from a complex interaction between genetic and …

The pathogenesis of autoimmunity remains to be fully elucidated, although the contribution
of genetic and environmental factors is generally recognized. Despite autoimmune …

The Environmental Determinants of Diabetes in the Young (TEDDY) study prospectively
follows 8,677 children enrolled from birth who carry HLA-susceptibility genotypes for …

Type 1 diabetes (T1D) results from the destruction of pancreatic beta cells through a process
that is primarily mediated by T cells. Emerging evidence suggests that dendritic cells (DCs) …

Autoimmune disorders derive from genetic, stochastic, and environmental factors that all
together interact in genetically predisposed individuals. The impact of an imbalanced gut …

Autoimmune type 1 diabetes is characterized by selective destruction of insulin-secreting
beta cells in the pancreas of genetically susceptible individuals. The mechanisms …

Thymoma-associated Myasthenia gravis (TAMG) is one of the anti-acetylcholine receptor
MG (AChR-MG) subtypes. The clinico-pathological features of TAMG and its pathogenesis …

Myasthenia gravis (MG) is an autoimmune disease affecting the neuromuscular junction
(NMJ), whose clinical hallmark is muscle weakness and early fatigability. The main target of …